N-叔丁氧羰基-2-哌啶甲酸乙酯

N-叔丁氧羰基-2-哌啶甲酸乙酯 - Names and Identifiers

Name	Ethyl 1-Boc-piperidine-2-carboxylate
Synonyms	N-Boc- Piperidine-2-carboxylate Ethyl N-Boc-Piperidine-2-Carboxylate ETHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE Ethyl 1-Boc-piperidine-2-carboxylate 1-tert-Butyl 2-ethyl piperidine-1,2-dicarboxylate 1-tert-butyl 2-ethyl piperidine-1,2-dicarboxylate 1-[3,3-dimethylbutoxy(oxo)methyl]-2-piperidinecarboxylic acid PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-ETHYL ESTER 1,2-Piperidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester 1,2-piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-ethyl ester N-Boc-Piperidine-2-carboxylate or ethyl 1-Boc-piperidine-2-carboxylate
CAS	362703-48-8
InChI	InChI=1/C13H23NO4/c1-5-17-11(15)10-8-6-7-9-14(10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3

N-叔丁氧羰基-2-哌啶甲酸乙酯 - Physico-chemical Properties

Molecular Formula	C13H23NO4
Molar Mass	257.33
Density	1.077±0.06 g/cm3(Predicted)
Boling Point	323.9±35.0 °C(Predicted)
Flash Point	149.7°C
Vapor Presure	0.000254mmHg at 25°C
pKa	-3.16±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.473

N-叔丁氧羰基-2-哌啶甲酸乙酯 - Introduction

Ethyl is an organic compound, commonly abbreviated as Boc-2-Pip-OEt. Its chemical formula is C12H21NO3 and its molecular weight is 227.3g/mol. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: a colorless to light yellow liquid
-Melting Point: Not Applicable
-Boiling point: approximately 106-108°C
-Solubility: Soluble in common organic solvents such as ethanol and dimethylformamide

Use:
- Ethyl is often used as an intermediate in organic synthesis.
-Because of the Boc protecting group, it can protect the amino group on the piperidine during the synthesis of the compound.
-It is commonly used in the preparation of active raw materials, drugs and pesticides in the pharmaceutical field.

Preparation Method:
Ethyl's preparation method can be carried out by the following steps:
1. Add acetyl chloride, sulfonyl chloride and tetrahydrofuran (THF) to dimethylformamide (DMF).
2. At low temperature, piperidine is added to the reaction system to react with the ions in DMF to generate piperidine formyl ethyl chloride.
3. Add piperidinecarboxylethyl chloride to ethylide benzoate (Boc2O) and alkali solution to generate Ethyl.

Safety Information:
- Ethyl is a chemical that requires appropriate laboratory safety and personal protective measures.
-Contact with skin may cause irritation. Wear goggles, lab coat, protective gloves, etc.
-Avoid inhaling the vapors or dust of the compound, and avoid ingestion or getting into the eyes.
-Store away from fire, high temperature and oxidizing agents.
-Regarding the specific use and treatment methods, the operation should be carried out in accordance with the safety data sheet of the chemical, and in accordance with relevant regulations and regulations.

Last Update：2024-04-09 21:04:16