N1-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)benzene-1,3-diamine
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediaMine
CAS: 1374507-24-0
Molecular Formula: C11H8ClF3N4
N1-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)benzene-1,3-diamine - Names and Identifiers
N1-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)benzene-1,3-diamine - Physico-chemical Properties
| Molecular Formula | C11H8ClF3N4 |
| Molar Mass | 288.66 |
| Density | 1.521±0.06 g/cm3(Predicted) |
| Boling Point | 439.7±45.0 °C(Predicted) |
| pKa | 4.03±0.10(Predicted) |
N1-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)benzene-1,3-diamine - Upstream Downstream Industry
| Downstream Products | CO-1686 |
N1-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)benzene-1,3-diamine - Introduction
N-[2-chloro-5-(trifluorometyl)-4-pyriMidinyl]-1,3-benzenediamine, also known as N-[2-chloro-5-(trifluorometyl)-4-pyrimidinyl]-1,3-benzenediamine, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is a solid with a white to yellow appearance. It is stable at room temperature, but decomposes under high temperature and light conditions. It is insoluble in water, but soluble in organic solvents such as dimethyl sulfoxide (DMSO) and chloroform.
Use:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is an important intermediate, which is used to synthesize drugs for the treatment of tumors. It is a third-generation tyrosine kinase inhibitor (TKI) that is used in the treatment of specific mutants in lung cancer. It has the effect of inhibiting tumor cell proliferation and apoptosis induction.
Method:
The preparation of N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine involves a multi-step organic synthesis process. The general synthetic route involves the conversion of 2-amino -3, 5-dinitro-p-nitrotoluene (an intermediate) to N-[2-chloro-5-(trifluoroMethyl) by reaction and purification steps.-4-pyriMidinyl]-1,3-benzenediamine.
Safety Information:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is a chemical that should be used with caution. During operation, Good Laboratory safety practices should be followed and appropriate protective equipment, such as lab gloves and goggles, should be worn. It may cause irritation and damage to the skin, eyes and respiratory system. If you come into contact with it, rinse immediately with plenty of water and seek medical help. In addition, N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine should be stored in a dry, cool and well-ventilated place, away from fire and oxidizing agents.
Nature:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is a solid with a white to yellow appearance. It is stable at room temperature, but decomposes under high temperature and light conditions. It is insoluble in water, but soluble in organic solvents such as dimethyl sulfoxide (DMSO) and chloroform.
Use:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is an important intermediate, which is used to synthesize drugs for the treatment of tumors. It is a third-generation tyrosine kinase inhibitor (TKI) that is used in the treatment of specific mutants in lung cancer. It has the effect of inhibiting tumor cell proliferation and apoptosis induction.
Method:
The preparation of N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine involves a multi-step organic synthesis process. The general synthetic route involves the conversion of 2-amino -3, 5-dinitro-p-nitrotoluene (an intermediate) to N-[2-chloro-5-(trifluoroMethyl) by reaction and purification steps.-4-pyriMidinyl]-1,3-benzenediamine.
Safety Information:
N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine is a chemical that should be used with caution. During operation, Good Laboratory safety practices should be followed and appropriate protective equipment, such as lab gloves and goggles, should be worn. It may cause irritation and damage to the skin, eyes and respiratory system. If you come into contact with it, rinse immediately with plenty of water and seek medical help. In addition, N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediamine should be stored in a dry, cool and well-ventilated place, away from fire and oxidizing agents.
Last Update：2024-04-09 20:52:54
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