N1-(4-Aminobutyl)guanidine
AGMATINE SULFATE ENDOGENOUS AGONIST AT
CAS: 306-60-5
Molecular Formula: C5H14N4
N1-(4-Aminobutyl)guanidine - Names and Identifiers
N1-(4-Aminobutyl)guanidine - Physico-chemical Properties
| Molecular Formula | C5H14N4 |
| Molar Mass | 130.19146 |
| Density | 1.20 |
| Boling Point | 235℃ |
| Flash Point | 96℃ |
| pKa | 13.78±0.70(Predicted) |
N1-(4-Aminobutyl)guanidine - Protective effect of Agmatine on vascular endothelial injury in septic mice
Author:
Zhu Junyu , Yang Xia , Rolly , Kang Wenyuan , Yin Shangqi , Yan army , Liang Huaping
Abstract:
Objective: to explore the effect of Agmatine on vascular endothelial function in septic mice. Methods: A mouse model of sepsis was established by cecal ligation and puncture (CLP). Forty-two 6-8 week-old male C57BL/6 mice were randomly divided into sham operation group (14 mice, intraperitoneal injection of phosphate buffer),CLP model Group (14 mice, intraperitoneal injection of phosphate buffer), in the agmatine-treated group (14 rats, intraperitoneal injection of 400mg/kg agmatine), mice in each group were sacrificed 24h after modeling and blood samples were collected, and liver and lung tissue samples were perfused. TNF-α, interleukin (IL-6,IL-10), intercellular adhesion molecule -1(ICAM-1) in serum were detected by enzyme-linked immunosorbent assay (ELISA), vascular adhesion molecule -1(VCAM-1), Vascular endothelial growth factor (VEGF), hemophilia coagulation factor (vWF), angiotensin -2(Ang-2), chemokine (MCP-1). The fluorescence intensity of liver and lung tissue lysates was detected by FITC-dextran fluorescence tracer method. Results: 24h after modeling, the abdomen of the CLP Group was light pink, the body temperature decreased, the spirit was poor, and the activity was reduced. After agmatine treatment, the spirit and activity of the mice were significantly improved. Compared with sham operation group, the content of vascular endothelial biomarkers in serum and plasma of CLP Group was significantly increased, and agmatine treatment could significantly inhibit its content (P0.01). At the same time, the fluorescence intensity of liver and lung tissue in CLP Group was significantly higher than that in sham operation group (P0.01), while agmatine could significantly reduce the fluorescence intensity of liver and lung tissue (P0.01). In addition, compared with sham surgery, In CLP Group, the levels of serum inflammatory factors were significantly increased (P0.01), while the expression of inflammatory mediators was significantly decreased after agmatine treatment (P0.01). Conclusion: agmatine can reduce the vascular permeability of liver and lung tissue by inhibiting the secretion of endothelial related molecules and inflammatory factors such as endothelial adhesion molecules, vascular endothelial growth factor and hemophilia coagulation factor, so as to alleviate the vascular endothelial injury in septic mice.expand
Key words:
agmatine sepsis vascular endothelium damage
meeting name:
The 12th annual meeting of the disaster medicine Professional Committee of the Chinese Society of Integrated Traditional and Western medicine and the 2016 high-end forum on disaster medicine and acute and critical diseases, the National follow-up project "cardiopulmonary resuscitation and critical care School",
"training course on Cardiopulmonary Resuscitation and Emergency and critical care" of Guangdong province
Meeting Time:
2016
cited:
Last Update：2024-01-02 23:10:35
N1-(4-Aminobutyl)guanidine - Relationship between the anti-physical dependence effect of agmatine and opioid receptors in rats
from hownet
Author:
Li Jin , Li Xin , Pei Steel , Qin Boyi
Abstract:
Objective: to observe the relationship between the anti-physical dependence effect of agmatine and opioid receptor in rats. Methods: The experiment was carried out by two methods: Rat physical dependence experiment and radioligand binding experiment. Results: Although agmatine could inhibit the withdrawal reaction of morphine dependent rats induced by naloxone in a dose-dependent manner, however, it has no inhibitory effect (no direct effect) on the binding reaction of 3h-naloxone to opioid receptors in rat forebrain, neither does it affect compensatory adaptive changes (without indirect effects) such as decreased affinity of opioid receptors for ligands and down-regulation of receptor numbers when physical dependence occurs. Conclusion: Although agmatine can inhibit opioid dependence, it has no direct or indirect effect on opioid receptors.Key words:
agmatine morphine opioid receptor Substance dependence
DOI:
10.3969/j.issn.1007-9718.1999.03.006
cited:
year:
1999
Last Update：2023-08-16 22:09:08
N1-(4-Aminobutyl)guanidine - New uses of agmatine
from Palm Bridge research
Application (patent) number:
CN 03102546
application date:
Feb 12, 2003
Public/Announcement Number:
CN 1520806 A
applicant (patent):
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, PLA
inventor:
Li Jin , Su Ruibin , New , Liu Yin
National and provincial code:
Beijing
cited:
Abstract:
The present invention relates to a new medical use of Agmatine. More particularly, the present invention relates to the use of agmatine in the preparation of a medicament for the prevention or treatment of Anxiety.
sovereignty:
1. Use of agmatine of the following formula in the manufacture of a medicament for the prevention and/or treatment of tumor diseases or symptoms .
Last Update：2023-08-16 22:09:08
N1-(4-Aminobutyl)guanidine - A method for the extraction of agmatine
from Baidu Library
Application (patent) number:
CN201610684104.8
application date:
2016-08-18
Public/Announcement Number:
CN106278954B
Public/announcement date:
2018.06.01
applicant (patent):
Jingjing Pharmaceutical Co., Ltd.
inventor:
Li Binshui , micro , he Lianshun , Zhang Xueyi , Zhang Yufeng
National and provincial code:
CN130528
Abstract:
The invention discloses a method for extracting agmatine, which relates to the technical field of extracting compounds. Including the following steps:(1) using arginine as raw material, under the action of arginine decarboxylase, the biological enzyme conversion liquid containing agmatine is freeze-thawed to make arginine decarboxylase lose biological activity;(2) take the inactivated biological enzyme conversion liquid for high-speed centrifugation to separate bacteria and protein substances to obtain centrifugal clear liquid;(3) pass the centrifugal clear liquid through the membrane system to remove bacterial debris and macromolecular substances, A clear solution of dialysis through the membrane is obtained;(4) the clear solution of dialysis through the membrane is concentrated, the activated carbon is decolorized, the pH is adjusted, and the solvent is crystallized, and the crude agmatine is filtered. The method can quickly process the crude agmatine, reduce the intermediate process of chemical reaction and reduce the impurities in the product. At the same time, the method has high productivity, low cost, simple operation and good product quality, the product quality and yield were improved, and good economic benefits were created.
Last Update：2023-08-16 22:09:08
N1-(4-Aminobutyl)guanidine - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-10 22:29:15
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