N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysine - Names and Identifiers
Name | Fmoc-D-Lys(Boc)-OH
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Synonyms | Fmoc-D-Lys(Boc)-OH Nα-FMoc-Nε-Boc-D-lysine N(e)-Boc-N(α)-Fmoc-D-lysine (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Lys(Boc)-OH Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-lysine N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysine N-alpha-(9-fluorenylmethyloxycarbonyl)-N-epsilon-t-butyl-oxycarbonyl-D-lysine (R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-6-((tert-butoxycarbonyl)aMino)hexanoic acid
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CAS | 92122-45-7
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EINECS | 804-633-0 |
InChI | InChI=1/C36H34N2O6/c39-34(40)33(38-36(42)44-22-32-29-17-7-3-13-25(29)26-14-4-8-18-30(26)32)19-9-10-20-37-35(41)43-21-31-27-15-5-1-11-23(27)24-12-2-6-16-28(24)31/h1-8,11-18,31-33H,9-10,19-22H2,(H,37,41)(H,38,42)(H,39,40)/t33-/m1/s1 |
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysine - Physico-chemical Properties
Molecular Formula | C26H32N2O6
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Molar Mass | 468.54 |
Density | 1.210±0.06 g/cm3(Predicted) |
Melting Point | 135-139°C |
Boling Point | 685.7±55.0 °C(Predicted) |
Flash Point | 458.9°C |
Solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMF (Sparingly) |
Vapor Presure | 1.36E-29mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
pKa | 3.88±0.21(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 2.2 ° (C=1, MeOH) |
MDL | MFCD00065660 |
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysine - Risk and Safety
Hazard Symbols | N - Dangerous for the environment
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Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
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Safety Description | S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
S24/25 - Avoid contact with skin and eyes.
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WGK Germany | 3 |
HS Code | 29225090 |
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysine - Introduction
N(ε)-Boc-N(α)-three-dimensional lysine (Fmoc-D-Lys(Boc)-OH) is an amino acid derivative comprising a protected lysine molecule and a Fmoc group. Here are some details about this compound:
Nature:
-Chemical formula: C24H29N3O6
-Molecular weight: 455.50g/mol
-Appearance: White crystal or crystalline powder
-freezing point: about 120-126°C
-Solubility: Soluble in some organic solvents, such as dimethylthiourea (DMF), dimethylformamide (DMF) and a small amount of ethanol
Use:
- Fmoc-D-Lys(Boc)-OH is one of the commonly used amino acid protecting groups in solid phase synthesis, which can be used as a starting material for the synthesis of polypeptides and proteins
-It is widely used in pharmaceutical research, biochemistry and protein synthesis
Method:
-The preparation of Fmoc-D-Lys(Boc)-OH is usually carried out by chemical synthesis methods under the guidance of nuclear magnetic resonance. This method involves Fmoc protection of Lys(Boc)-OH and is typically carried out under basic conditions. The final product is obtained by crystallization or purification.
Safety Information:
- Fmoc-D-Lys(Boc)-OH is relatively stable under general conditions of use. However, since it is a chemical, it is still necessary to pay attention to safe operation measures.
-Avoid inhalation, ingestion or contact with skin and eyes.
-Wear protective gloves, eye protection, and a suitable lab coat for use.
-Follow appropriate laboratory safety regulations and operating guidelines when handling and storing chemicals.
Last Update:2024-04-09 19:05:53