| biological activity | Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective β-adrenergic receptor antagonist with antihypertensive and antiarrhythmic activity. |
| target | TargetValue β-adrenergic receptor () |
| Target | Value |
| in vitro study | in human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a k I value of 19.4 μ m. with respect to Nadolol, the k m for OATP1A2 is 84 μ m. |
| in vivo study | in male OF1 bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
| chemical properties | crystalline powder. Melting point 124-136 ℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone and benzene. |
| use | antiarrhythmic drugs. |
| production method | cis -5,6,7,8-tetrahydro -1,6,7-naphthol (melting point 188-188.5 ℃) is prepared from 5,8-dihydro -1-naphthol, and then react with sodium methoxide, dimethyl sulfoxide and 3-chloro -1,2-propylene oxide to produce 2,3-cis -1,2,3,4-tetraoxy -5-[2,3-(epoxy) propoxy]-2,3-naphthol diol, and then react with tert-butylamine to obtain naphthalene hydroxy. |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
