NE
norepinephrine
CAS: 51-41-2
Molecular Formula: C8H11NO3
NE - Names and Identifiers
| Name | norepinephrine |
| Synonyms | NE aktamin adrenor Arterenol (-)-noradrec noradrenalin norepinephrine d-(-)-noradrenaline arterenolfreebase(noradrenaline) 4-(2-amino-2-hydroxyethyl)benzene-1,2-diol 4-(2-amino-1-hydroxyethyl)-2-benzenedio(r)- (-)-alpha-(aminomethyl)protocatechuylalcohol |
| CAS | 51-41-2 |
| EINECS | 200-096-6 |
| InChI | InChI=1/C8H11NO3/c9-8(12)4-5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 |
NE - Physico-chemical Properties
| Molecular Formula | C8H11NO3 |
| Molar Mass | 169.18 |
| Density | 1.2435 (rough estimate) |
| Melting Point | 220-230°C |
| Boling Point | 298.46°C (rough estimate) |
| Specific Rotation(α) | D25 -37.3° (c = 5 in water with 1 equiv HCl) |
| Flash Point | 190.9°C |
| Water Solubility | Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether. |
| Solubility | Soluble in DMSO |
| Vapor Presure | 7.51E-07mmHg at 25°C |
| Appearance | Crystallization |
| Color | off-white to tan |
| Merck | 14,6695 |
| BRN | 4231961 |
| pKa | 8.64(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20C. |
| Sensitive | Air & Light Sensitive |
| Refractive Index | 1.5100 (estimate) |
| MDL | MFCD00025592 |
NE - Risk and Safety
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R34 - Causes burns R11 - Highly Flammable R28 - Very Toxic if swallowed |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S20 - When using, do not eat or drink. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DN5950000 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29225090 |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80 |
NE - Reference
| Reference Show more | 1. Wang Zhentao, Yan Jingjing, Wu Hong, Chang Hongbo, Xu Wenwen, Li Qiaozhi. Effects of Kangxian Yixin recipe on norepinephrine-induced apoptosis and expression of apoptosis-related factors in H9c2 cardiomyocytes [J]. Journal of Traditional Chinese Medicine, 2019,60(21):1866-1869. 2. Liu Yafang, Wang Ning. Effects of tongqiao huoxue decoction on blood-brain barrier permeability and monoamine neurotransmitter content in brain of mice with cerebral ischemia-reperfusion [J]. Anhui medical journal, 2015,19(05):842-845. 3. Zhou-yue, Fu Min, Liu Huan. Study on theanine combined with gamma-aminobutyric acid to improve depressive symptoms in CUMS rats [C]// nutrition research and clinical practice-the 14th National Nutrition Science Conference and the 11th Asia Pacific Clinical Nutrition Conference, the second global conference of Chinese nutrition scientists. 2020:298-303 312. 4. Bi Xinning, Qi Yi, Huang Yunfang, Wei Guijie, Zhang Ting, Wang Hongya, Wang Shuqi, Li Zhihui, Zheng Wei, Wang Qi, Zhang Yujie. Simultaneous and rapid determination of 8 neurotransmitters in tissues, blood and urine samples of rats by UPLC-MS/MS [J]. Chinese Journal of Traditional Chinese Medicine, 2019,44(22):4918-4923. 5. An, Jia, et al. "Carbon dots-based dual-emission proportional fluorescence sensor for dopamine detection." Spectrochimica Acta Part A: Molecular and biomolevical spectroscope 243 (2020): 118804.https://doi.org/10.1016/j.saa.2020.118804 6. Sun, Xiaoshu, et al. "Anti-convulsant effects of cultures bear bile powder in febrile seizure via regulation of neurotransmission and inhibition of neuroinflammation." Journal of Ethnopharmacology 262 (2020): 112998.https://doi.org/10.1016/j.jep.2020.11299 7. [IF=2.952] Chungang Liu et al."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters."Mol Med Rep. 2017 Aug;16(2):2172-2178 8. [IF=2.877] Tao Wu et al."Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats."Chronobiol Int. 2017;34(1):78-92 9. [IF=13.273] Jia An et al."Multichannel ratiometric fluorescence sensor arrays for rapid visual monitoring of epinephrine, norepinephrine, and levodopa."Chem Eng J. 2021 Dec;425:130595 10. [IF=4.641] Fei Qu et al."Aggregation-induced emission of lead halide perovskites modulated by dispersed/aggregated gold nanoparticles for application in the detection of dopamine."Mater Res Bull. 2021 Oct;142:111405 11. [IF=4.098] Jia An et al."Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection."Spectrochim Acta A. 2020 Dec;243:118804 12. [IF=3.932] Yiwen Yang et al."Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters."Ann Transl Med. 2021 Oct; 9(20): 1524 13. [IF=3.69] Xiaoshu Sun et al."Anti-convulsant effects of cultures bear bile powder in febrile seizure via regulation of neurotransmission and inhibition of neuroinflammation."J Ethnopharmacol. 2020 Nov;262:112998 |
NE - Introduction
No odor, bitter taste, easy to deteriorate in light and air. Soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether.
Last Update：2022-10-16 17:25:41
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Product Name: Adrenaline Impurity 2(Adrenaline EP Impurity B) Visit Supplier Webpage Request for quotationCAS: 51-41-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Norepinephrine Visit Supplier Webpage Request for quotationCAS: 51-41-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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