Name | NFPS |
Synonyms | NFPS N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine 2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid Glycine, N-[3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methyl- 2-((3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid |
CAS | 405225-21-0 |
Molecular Formula | C24H24FNO3 |
Molar Mass | 393.45 |
Storage Condition | Store at +4°C |
biological activity | NFPS is a selective, non-competitive inhibitor of Glycine transporter -1 (GlyT1), the IC50 for hGlyT1 and rGlyT1 were 2.8 nM and 9.8 nM, respectively. NFPS exerts a neuroprotective effect in a rat model of transient focal cerebral ischemia and reperfusion via the glyR alpha1 subunit. |