Molecular Formula | C29H30F3N5O2 |
Molar Mass | 537.58 |
Density | 1.313±0.06 g/cm3(Predicted) |
Appearance | powder |
Color | white to beige |
pKa | 12.91±0.70(Predicted) |
Storage Condition | 2-8°C |
In vitro study | NG25 inhibits phosphorylation of proteins downstream of TAK1 and MAP4K2, such as IKK, p38, and JNK, at concentrations less than 100 nM. |
UN IDs | UN 2811 6.1 / PGIII |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.86 ml | 9.301 ml | 18.602 ml |
5 mM | 0.372 ml | 1.86 ml | 3.72 ml |
10 mM | 0.186 ml | 0.93 ml | 1.86 ml |
5 mM | 0.037 ml | 0.186 ml | 0.372 ml |
biological activity | NG25 is a novel TAK1 inhibitor, the IC50 for TAK1 and MAP4K2 were 149 nM and 21.7 nM, respectively. |
Target | TargetValue TAK1 () MAP4K2 () |
Target | Value |
in vitro study | NG25 inhibits the phosphorylation of downstream proteins of TAK1 and MAP4K2 at concentrations less than 100 nM, such as IKK, p38, and JNK. |