NH2-PEG8-CH2CH2COOtBu
Amino-PEG8-t-butyl ester
CAS: 756526-06-4
Molecular Formula: C23H47NO10
NH2-PEG8-CH2CH2COOtBu - Names and Identifiers
NH2-PEG8-CH2CH2COOtBu - Physico-chemical Properties
| Molecular Formula | C23H47NO10 |
| Molar Mass | 497.62 |
| Density | 1.067±0.06 g/cm3(Predicted) |
| Boling Point | 544.3±45.0 °C(Predicted) |
| pKa | 8.74±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Physical and Chemical Properties | Bioactive Amino-PEG8-Boc is a degradable (cleavable) 8-unit PEG-ADC linker used in the synthesis of antibody-coupled drugs (ADCs). Amino-PEG8-Boc is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
NH2-PEG8-CH2CH2COOtBu - Upstream Downstream Industry
| Raw Materials | OCTAETHYLENE GLYCOL tert-Butyl acrylate |
NH2-PEG8-CH2CH2COOtBu - Reference Information
| biological activity | Amino-PEG8-Boc is a degradable (cleavable) 8-unit PEG-ADC link for the synthesis of antibody-coupled drugs (ADC). Amino-PEG8-Boc is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
| target | Cleavable Alkyl/ether PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 20:52:54
NH2-PEG8-CH2CH2COOtBu - Uses and synthesis methods
target
Cleavable
Alkyl/ether
PEGs
in vitro study
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Last Update：2024-04-10 22:41:03
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Product Name: H2N-PEG8-CH2CH2COOtBu Visit Supplier Webpage Request for quotation
CAS: 756526-06-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 756526-06-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Raw Materials for NH2-PEG8-CH2CH2COOtBu