NHS-PEG-NHS

NHS-PEG-NHS - Names and Identifiers

Name	NHS-PEG-NHS
Synonyms	NHS-PEG-NHS BIS-PEG9-NHS NHS-PEG24-NHS NHS-PEG16-NHS Bis-PE21- NHS ester Bis-PEG21-NHS Ester α,ω-disuccinimidyl octaethylene glycol α,ω-disuccinimidyl nonaethylene glycol α,ω-disuccinimidyl dodecaethylene glycol
CAS	1008402-79-6

NHS-PEG-NHS - Physico-chemical Properties

Molecular Formula	C30H48N2O17
Molar Mass	708.71
Density	1.31±0.1 g/cm3(Predicted)
Boling Point	737.0±70.0 °C(Predicted)
Appearance	solid or viscous liquid
Color	Colorless to Light orange to Yellow
Storage Condition	-20°C
In vitro study	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

NHS-PEG-NHS - Reference Information

biological activity

Bis-PEG9-NHS ester is a PROTAC Bridge belonging to the PEG class and the Alkyl/ether class. Bis-PEG9-NHS ester can be used to synthesize a range of PROTAC molecules. Bis-PEG9-NHS ester is a cleavable ADC attachment Bridge used in the synthesis of antibody drug conjugates (ADCs).

Last Update：2024-04-09 02:00:13