NITD-916 - Names and Identifiers
NITD-916 - Physico-chemical Properties
| Molecular Formula | C20H25NO2
|
| Molar Mass | 311.42 |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Boling Point | 488.7±45.0 °C(Predicted) |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
NITD-916 - Reference Information
| biological activity | NITD-916 is a 4-hydroxy-2-pyridone derivative, it is an orally active and highly lipophilic inhibitor of mycobacterial enoyl reductase InhA with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to prevent entry into the fatty acyl substrate binding pocket. NITD-916 has effective anti tuberculosis effect. |
| Target | IC50: 570 nM (InhA) |
Last Update：2024-04-09 02:00:14
