NSC 683551
Incyclinide
CAS: 15866-90-7
Molecular Formula: C19H17NO7
NSC 683551 - Names and Identifiers
NSC 683551 - Physico-chemical Properties
| Molecular Formula | C19H17NO7 |
| Molar Mass | 371.34 |
| Density | 1.70±0.1 g/cm3(Predicted) |
| Melting Point | 228-231 °C |
| Boling Point | 752.8±60.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%. |
| In vivo study | Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix. |
NSC 683551 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.693 ml | 13.465 ml | 26.929 ml |
| 5 mM | 0.539 ml | 2.693 ml | 5.386 ml |
| 10 mM | 0.269 ml | 1.346 ml | 2.693 ml |
| 5 mM | 0.054 ml | 0.269 ml | 0.539 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: CMT-3; COL-3 Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Incyclinide Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Incyclinide Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Incyclinide Visit Supplier Webpage Request for quotation
CAS: 15866-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 15866-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: CMT-3; COL-3 Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Incyclinide Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Incyclinide Visit Supplier Webpage Request for quotationCAS: 15866-90-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Incyclinide Visit Supplier Webpage Request for quotation
CAS: 15866-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 15866-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History