NSC-46077

Name	7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazpine-2-one-4-oxide
Synonyms	ro5-2092 NSC-46007 NSC-46077 Demoxepam Ro 5-2092 ro5-2092lactam Ro 5-2092 lactam Chlordiazepoxide lactam 4-benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-2h-4-oxide 4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-phenyl-2h-4-oxide 1,3-dihydro-7-chloro-5-phenyl-2h-1,4-benzodiazepin-2-one4-oxide 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-4-oxid 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazpine-2-one-4-oxide 1,3-Dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide 7-chloro-4-hydroxy-5-phenyl-3,4-dihydro-2H-1,4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-, 4-oxide 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-, 4-oxide
CAS	963-39-3
EINECS	213-515-2
InChI	InChI=1/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)

Molecular Formula	C15H11ClN2O2
Molar Mass	286.71
Density	1.40±0.1 g/cm3(Predicted)
Melting Point	235-236 °C (decomp)
Flash Point	2℃
pKa	pKa 4.5 (Uncertain)
Storage Condition	-20°C
Refractive Index	1.682
Physical and Chemical Properties	crystals (dichloromethane/hexane). Melting point 239-241 °c.
Use	Intermediate of Anning, Shuning (noroxazepam).

Risk Codes	R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 1648 3 / PGII
WGK Germany	3
HS Code	2933996100

NIST chemical information	information provided by: webbook.nist.gov (external link)
biological activity	demoxepa is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxic activity against cancer cell lines. Demoxepam has anticonvulsant and anti-Anxiety effect.
Use	an intermediate of Seroquel (noroxazepam).
production method	cyclization of p-nitrochlorobenzene with benzyl nitrile in ethanol with sodium hydroxide, 5-chloro-3-phenylbenzylisoxazole is produced, and then it is reduced with iron powder-hydrochloric acid and ring-opened to obtain 2-amino-5-chlorobenzophenone, further, 2-amino-5-chlorobenzophenone oxime was obtained by oximation with hydroxylamine hydrochloride. The latter is cyclized with Chloroacetyl Chloride to give 6-chloro-2-chloromethyl-4-phenylquinazoline -3-oxide, which is then expanded under the action of sodium hydroxide to give the product.

Last Update：2024-04-10 22:29:15

Spot supply

Product Name: Oxazepam Impurity 5 (Oxazepam EP Impurity E) Visit Supplier Webpage Request for quotation
CAS: 963-39-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: Oxazepam Impurity 5 (Oxazepam EP Impurity E) Visit Supplier Webpage Request for quotation
CAS: 963-39-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

View History

NSC-46077

NSC-46077 Request for Quotation