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NSC-9701

17-methyltestosterone

CAS: 58-18-4

Molecular Formula: C20H30O2

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NSC-9701 - Names and Identifiers

Name 17-methyltestosterone
Synonyms Nu-man
NSC-9701
Oraviron
MESTERONE
METANDREN
mtmucorettes
Neo-Hombreol-M
Neo-Homobreol (M)
Methyltestosterone
17-methyltestosterone
17-hydroxy-17-methylandrost-4-en-3-one
(17beta)-17-hydroxy-17-methylandrost-4-en-3-one
17beta-hydroxy-17alpha-methylandrost-4-en-3-one
CAS 58-18-4
EINECS 200-366-3
InChI InChI=1/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1
InChIKey GCKMFJBGXUYNAG-HLXURNFRSA-N

NSC-9701 - Physico-chemical Properties

Molecular FormulaC20H30O2
Molar Mass302.46
Density1.0434 (rough estimate)
Melting Point162-168°C(lit.)
Boling Point383.47°C (rough estimate)
Specific Rotation(α)79 º (c=1, alcohol)
Flash Point5°C
Water Solubility33.88mg/L(25 ºC)
Solubility H2O: ≤0.5mg/mL
Vapor Presure2.28E-09mmHg at 25°C
Appearancesolid (photosensitive)
Colorwhite
Merck13,6148
BRN2057425
pKa15.13±0.60(Predicted)
Storage Condition2-8°C
Refractive Index1.4800 (estimate)
Physical and Chemical Properties
melting point 162-168°C
specific rotation 79 ° (c = 1, alcohol)

NSC-9701 - Risk and Safety

Risk CodesR45 - May cause cancer
R63 - Possible risk of harm to the unborn child
R22 - Harmful if swallowed
R20 - Harmful by inhalation
R19 - May form explosive peroxides
R11 - Highly Flammable
R61 - May cause harm to the unborn child
R60 - May impair fertility
R36/37/38 - Irritating to eyes, respiratory system and skin.
R38 - Irritating to the skin
R10 - Flammable
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25 - Avoid contact with skin and eyes.
S22 - Do not breathe dust.
UN IDs3249
WGK Germany3
RTECSBV8400000
HS Code29372900
Hazard Class6.1(b)
Packing GroupIII

NSC-9701 - Standard

Authoritative Data Verified Data

This product is 17a-methyl-17b-hydroxyandrostin-4-en-3-one. The C20H30O2 content shall be between 97.0% and 103.0% calculated on the dried product.

Last Update：2024-01-02 23:10:35

NSC-9701 - Trait

Authoritative Data Verified Data
  • This product is white or off-white crystalline powder; Odorless, tasteless; Slightly hygroscopic.
  • This product is soluble in ethanol, acetone or chloroform, slightly soluble in ether, slightly soluble in vegetable oil, insoluble in water.

melting point

The melting point of this product (General 0612) is 163~167°C.

specific rotation

take this product, precision weighing, plus ethanol dissolution and quantitative dilution of about 10 mg per lml solution, according to the law (General 0621), the specific rotation was 79 ° to 85 °.

Last Update：2022-01-01 11:38:40

NSC-9701 - Differential diagnosis

Authoritative Data Verified Data
  1. take 5mg of this product, add sulfuric acid-ethanol (2:l ) lml to dissolve, that is, yellow and yellow-green fluorescence.
  2. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 120).
Last Update：2022-01-01 11:38:40

NSC-9701 - Exam

Authoritative Data Verified Data

Related substances

take this product, add methanol to dissolve and dilute to make a solution containing about 0.6mg per 1 ml as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to the scale with methanol and shaken. According to the chromatographic conditions under the content determination item, 10ul of each of the test solution and the control solution are accurately measured and injected into the liquid chromatograph respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are no more than 3 impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be more than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.75 times (1.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.025 times smaller than the main peak area of the control solution were ignored.

loss on drying

take this product, dry at 105°C for 2 hours, loss of weight shall not exceed 1.0% (General rule 0831).

Last Update：2022-01-01 11:38:41

NSC-9701 - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

using eighteen alkyl silane bonded silica gel as filler; Methanol-water (72:28) as mobile phase; The detection wavelength was 241rmu, methanol was added to dissolve and quantitatively diluted to prepare about 0.lmg solution, take 10ul injection liquid chromatograph, record chromatogram, theoretical plate number calculated by methyltestosterone peak is not less than 1500, methyltestosterone peak and testosterone peak separation should meet the requirements.

assay

take about 10mg of this product, weigh it accurately, put it in a lOOml measuring flask, add methanol to dissolve and dilute it to the scale, shake it well, and use it as a test solution, take 10u1 injection liquid chromatograph, record chromatogram; Take methyltestosterone control, same method determination. According to the external standard method to calculate the peak area, that is.

Last Update：2022-01-01 11:38:41

NSC-9701 - Category

Authoritative Data Verified Data

androgens.

Last Update：2022-01-01 11:38:42

NSC-9701 - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:38:42

NSC-9701 - Methyltestosterone Tablets

Authoritative Data Verified Data

This product contains E. Coli (C20H3002) should be 90.0% ~ 110.0% of the label amount.

trait

This product is white tablet.

identification

take an appropriate amount of fine powder of this product (about 10 mg of methyltestosterone), add ethanol or chloroform 10mU and stir to dissolve methyltestosterone, filter, and evaporate the filtrate on a water bath, the residue was identified according to the test of item (1) and item (3) under the item of methyltestosterone, and showed the same result.

examination

  • Content uniformity take 1 tablet of this product, put it in a 50ml measuring flask, add an appropriate amount of methanol, sonicate to dissolve methyltestosterone, let it cool, dilute to the scale with methanol, shake well, filter, the content of the continued filtrate shall be determined according to the method under the content determination item, and shall comply with the regulations (General rule 0941).
  • the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), with ethanol solution (5-100) 500ml as the dissolution medium, the rotation speed is rpm, operate in accordance with the law, after 45 minutes, take the solution filtration, take the filtrate, according to UV-visible spectrophotometry (General rule 0401), at the wavelength of 249nm absorbance measurement; Another methyltestosterone control, precision weighing, plus ethanol solution (5-100) dissolved and quantitatively diluted into each lml containing about Loug solution, the same method to determine, calculate the dissolution of each tablet. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 10mg equivalent to methyltestosterone), put it in a 100ml measuring flask, add the appropriate amount of methanol, ultrasound to dissolve methyltestosterone, cool, dilute to the scale with methanol, shake well, filter, take the filtrate and measure it according to the method under the item of methyltestosterone content determination.

category

Same as methyltestosterone.

specification

5mg

storage

light shielding, sealed storage.

Last Update：2022-01-01 11:38:43
NSC-9701
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 17-methyltestosterone Request for quotation
CAS: 58-18-4
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Jiangsu Pules Biotechnology Co.,Ltd.
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CAS: 58-18-4
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 58-18-4
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Shanghai Worldyang Chemical Co.,Ltd.
Product Name: 17-Methyltestosterone Request for quotation
CAS: 58-18-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
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Wechat: 13651600618
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 17-methyltestosterone Request for quotation
CAS: 58-18-4
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 17-methyltestosterone Request for quotation
CAS: 58-18-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Methyltestosterone Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 17-methyltestosterone Request for quotation
CAS: 58-18-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: 17-Methyltestosterone Request for quotation
CAS: 58-18-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
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NSC-9701
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