Napellonin
Bullatine G
CAS: 509-24-0
Molecular Formula: C22H31NO3
Napellonin - Names and Identifiers
Napellonin - Physico-chemical Properties
| Molecular Formula | C22H31NO3 |
| Molar Mass | 357.49 |
| Density | 1.29 |
| Melting Point | 201-203℃ |
| Boling Point | 535.8±50.0 °C(Predicted) |
| Specific Rotation(α) | D20 -135.4° |
| Flash Point | 277.8℃ |
| pKa | 14.20±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Aconitum and Aconitum. |
| In vivo study | Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorineinhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD 50 and ED 50 values of 142 mg and 7.3mg, respectively. |
Napellonin - Risk and Safety
| Toxicity | LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset) |
Napellonin - Introduction
Bullatine G is a natural product, belonging to the alkaloid group of compounds. It is mainly found in plants of the yellow flower family, such as Robinia pseudoacacia and Polygonum spinosa.
Bullatine G has a unique chemical structure and biological activity. It is a polycyclic aromatic compound with antibacterial, anti-inflammatory and anti-tumor biological activities. Its chemical structure contains nitrogen atoms, making it basic in nature.
Bullatine G has a wide range of applications in the field of medicine. It can be used as an antibacterial agent for the treatment of infectious diseases. In addition, it has anti-inflammatory effects and can be used to treat inflammation and pain symptoms. Some studies have also shown that Bullatine G may have an inhibitory effect on some tumors, so it also has potential application value in tumor treatment.
As for the preparation method of Bullatine G, the method of extracting from the yellow flower family plants is mainly used at present. The extraction process usually involves the collection, drying and crushing of plant material, followed by extraction with solvents, and finally pure Bullatine G through isolation and purification.
When using Bullatine G, you need to pay attention to its safety. Due to its alkaline nature and irritation to the skin and eyes, care should be taken to use personal protective equipment during operation and avoid contact with the skin, eyes and respiratory tract. In addition, appropriate storage and handling measures are required to ensure its stability and safety.
In General, Bullatine G is an alkaloid with antibacterial, anti-inflammatory and anti-tumor activities. It has important application prospects in the field of medicine, but safety issues need to be paid attention to during use.
Bullatine G has a unique chemical structure and biological activity. It is a polycyclic aromatic compound with antibacterial, anti-inflammatory and anti-tumor biological activities. Its chemical structure contains nitrogen atoms, making it basic in nature.
Bullatine G has a wide range of applications in the field of medicine. It can be used as an antibacterial agent for the treatment of infectious diseases. In addition, it has anti-inflammatory effects and can be used to treat inflammation and pain symptoms. Some studies have also shown that Bullatine G may have an inhibitory effect on some tumors, so it also has potential application value in tumor treatment.
As for the preparation method of Bullatine G, the method of extracting from the yellow flower family plants is mainly used at present. The extraction process usually involves the collection, drying and crushing of plant material, followed by extraction with solvents, and finally pure Bullatine G through isolation and purification.
When using Bullatine G, you need to pay attention to its safety. Due to its alkaline nature and irritation to the skin and eyes, care should be taken to use personal protective equipment during operation and avoid contact with the skin, eyes and respiratory tract. In addition, appropriate storage and handling measures are required to ensure its stability and safety.
In General, Bullatine G is an alkaloid with antibacterial, anti-inflammatory and anti-tumor activities. It has important application prospects in the field of medicine, but safety issues need to be paid attention to during use.
Last Update：2024-04-09 21:54:55
