Molecular Formula | C22H31NO3 |
Molar Mass | 357.49 |
Density | 1.29 |
Melting Point | 201-203℃ |
Boling Point | 535.8±50.0 °C(Predicted) |
Specific Rotation(α) | D20 -135.4° |
Flash Point | 277.8℃ |
pKa | 14.20±0.60(Predicted) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Aconitum and Aconitum. |
In vivo study | Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorineinhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD 50 and ED 50 values of 142 mg and 7.3mg, respectively. |
Toxicity | LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset) |