Naphthyridine
Naphthyridine
CAS: 253-72-5
Molecular Formula: C8H6N2
Naphthyridine - Names and Identifiers
| Name | Naphthyridine |
| Synonyms | Naphthyridine 6-Naphthyridine 1,6-NAPHTHYRIDINE 1,6-Naphthyridine 1,6-Pyridopyridine 1,6-DIAZANAPHTHALENE PYRIDO[4,3-B]PYRIDINE 1,6-Naphthyridine(6CI,7CI,8CI,9CI) |
| CAS | 253-72-5 |
| InChI | InChI=1/C8H6N2/c1-2-7-6-9-5-3-8(7)10-4-1/h1-6H |
Naphthyridine - Physico-chemical Properties
| Molecular Formula | C8H6N2 |
| Molar Mass | 130.15 |
| Density | 1.183±0.06 g/cm3(Predicted) |
| Melting Point | 231-233°C |
| Boling Point | 267.3±13.0 °C(Predicted) |
| Flash Point | 35 °C |
| Vapor Presure | 0.0136mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | 3.70±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.653 |
| MDL | MFCD00059750 |
Naphthyridine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
Naphthyridine - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | 1,5-naphthalene is a pharmaceutical intermediate, which can be prepared from 4-aminopyridine as a starting material and can be used to prepare CXCR4 inhibitors. |
| preparation | concentrated sulfuric acid (30mL) is slowly added into 20mL of water, D22-1(3.76g,40.0mmol), glycerin (12.52g,136mmol) and sodium m-nitrobenzene sulfonate (19.8g,88.0mmol) are sequentially added, heated to 130 ℃, and stirred overnight. Add 2N sodium hydroxide aqueous solution to adjust PH to 10, filter, add dichloromethane (2*200mL) for secondary extraction, combine organic phases, concentrate under reduced pressure, and purify by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1 to 1:1) to obtain yellow-white solid intermediate D22-2, namely 1,5-naphthalene (900mg,69%). |
Last Update：2024-04-10 22:29:15
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