Nefopanhydrochloride
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
CAS: 13669-70-0
Molecular Formula: C17H19NO
Nefopanhydrochloride - Names and Identifiers
Nefopanhydrochloride - Physico-chemical Properties
| Molecular Formula | C17H19NO |
| Molar Mass | 253.34 |
| Density | 1.0078 (rough estimate) |
| Boling Point | 396.54°C (rough estimate) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5400 (estimate) |
| Physical and Chemical Properties | Chemical properties Its hydrochloride is white crystalline powder. Melting point 238-242 ℃. Soluble in water, chloroform and methanol. It tastes bitter. |
| Use | Uses this strain of non-addictive analgesics, with muscle relaxant effect. Suitable for all kinds of postoperative pain, cancer pain, visceral smooth muscle colic, etc. For postoperative pain, cancer pain, acute external pain treatment, also suitable for acute gastritis, biliary ascariasis, ureteral calculi and other visceral smooth muscle colic |
Nefopanhydrochloride - Upstream Downstream Industry
Nefopanhydrochloride - Uses and synthesis methods
use
Pingtongxin (nefopam, Nefopam), the chemical name is 5-methyl -1-phenyl -3,4,5, 6-tetrahydro-1H-2, 5-oxynitrogen benzoxine, It is a non-narcotic analgesic first synthesized by Klohs et al. in 1972. Subsequently, the drug was widely used in Europe, North America, South America and other countries.
production method
The reaction of 2-benzoylbenzoic acid with thionyl chloride, and then with 2-methylaminoethanol to prepare 2-[[N-(2-hydroxyethyl)-N-methyl] amine] methyl diphenylmethanol, it is heated with p-toluenesulfonic acid and benzene to evaporate the benzene, and the resulting oil is alkalized to obtain the nefopam salt.
Last Update：2024-04-10 22:29:15
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CAS: 13669-70-0
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Product Name: 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Visit Supplier Webpage Request for quotation
CAS: 13669-70-0
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CAS: 13669-70-0
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View History
Raw Materials for Nefopanhydrochloride
Thionyl chloride
p-Toluenesulfonic acid
Potassium borohydride
PARA TOLUENE
2-Benzoylbenzoic acid
2-Methylaminoethanol
p-Toluenesulfonic acid
Potassium borohydride
PARA TOLUENE
2-Benzoylbenzoic acid
2-Methylaminoethanol