Neo-Homobreol (M)
17-methyltestosterone
CAS: 58-18-4
Molecular Formula: C20H30O2
Neo-Homobreol (M) - Names and Identifiers
| Name | 17-methyltestosterone |
| Synonyms | Nu-man NSC-9701 Oraviron MESTERONE METANDREN mtmucorettes Neo-Hombreol-M Neo-Homobreol (M) Methyltestosterone 17-methyltestosterone 17-hydroxy-17-methylandrost-4-en-3-one (17beta)-17-hydroxy-17-methylandrost-4-en-3-one 17beta-hydroxy-17alpha-methylandrost-4-en-3-one |
| CAS | 58-18-4 |
| EINECS | 200-366-3 |
| InChI | InChI=1/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1 |
| InChIKey | GCKMFJBGXUYNAG-HLXURNFRSA-N |
Neo-Homobreol (M) - Physico-chemical Properties
| Molecular Formula | C20H30O2 |
| Molar Mass | 302.46 |
| Density | 1.0434 (rough estimate) |
| Melting Point | 162-168°C(lit.) |
| Boling Point | 383.47°C (rough estimate) |
| Specific Rotation(α) | 79 º (c=1, alcohol) |
| Flash Point | 5°C |
| Water Solubility | 33.88mg/L(25 ºC) |
| Solubility | H2O: ≤0.5mg/mL |
| Vapor Presure | 2.28E-09mmHg at 25°C |
| Appearance | solid (photosensitive) |
| Color | white |
| Merck | 13,6148 |
| BRN | 2057425 |
| pKa | 15.13±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4800 (estimate) |
| Physical and Chemical Properties | melting point 162-168°C specific rotation 79 ° (c = 1, alcohol) |
Neo-Homobreol (M) - Risk and Safety
| Risk Codes | R45 - May cause cancer R63 - Possible risk of harm to the unborn child R22 - Harmful if swallowed R20 - Harmful by inhalation R19 - May form explosive peroxides R11 - Highly Flammable R61 - May cause harm to the unborn child R60 - May impair fertility R36/37/38 - Irritating to eyes, respiratory system and skin. R38 - Irritating to the skin R10 - Flammable |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | BV8400000 |
| HS Code | 29372900 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Neo-Homobreol (M) - Standard
Authoritative Data Verified Data
This product is 17a-methyl-17b-hydroxyandrostin-4-en-3-one. The C20H30O2 content shall be between 97.0% and 103.0% calculated on the dried product.
Last Update：2024-01-02 23:10:35
Neo-Homobreol (M) - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless, tasteless; Slightly hygroscopic.
- This product is soluble in ethanol, acetone or chloroform, slightly soluble in ether, slightly soluble in vegetable oil, insoluble in water.
melting point
The melting point of this product (General 0612) is 163~167°C.
specific rotation
take this product, precision weighing, plus ethanol dissolution and quantitative dilution of about 10 mg per lml solution, according to the law (General 0621), the specific rotation was 79 ° to 85 °.
Last Update：2022-01-01 11:38:40
Neo-Homobreol (M) - Differential diagnosis
Authoritative Data Verified Data
- take 5mg of this product, add sulfuric acid-ethanol (2:l ) lml to dissolve, that is, yellow and yellow-green fluorescence.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 120).
Last Update：2022-01-01 11:38:40
Neo-Homobreol (M) - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and dilute to make a solution containing about 0.6mg per 1 ml as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to the scale with methanol and shaken. According to the chromatographic conditions under the content determination item, 10ul of each of the test solution and the control solution are accurately measured and injected into the liquid chromatograph respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are no more than 3 impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be more than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.75 times (1.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.025 times smaller than the main peak area of the control solution were ignored.
loss on drying
take this product, dry at 105°C for 2 hours, loss of weight shall not exceed 1.0% (General rule 0831).
Last Update：2022-01-01 11:38:41
Neo-Homobreol (M) - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
using eighteen alkyl silane bonded silica gel as filler; Methanol-water (72:28) as mobile phase; The detection wavelength was 241rmu, methanol was added to dissolve and quantitatively diluted to prepare about 0.lmg solution, take 10ul injection liquid chromatograph, record chromatogram, theoretical plate number calculated by methyltestosterone peak is not less than 1500, methyltestosterone peak and testosterone peak separation should meet the requirements.
assay
take about 10mg of this product, weigh it accurately, put it in a lOOml measuring flask, add methanol to dissolve and dilute it to the scale, shake it well, and use it as a test solution, take 10u1 injection liquid chromatograph, record chromatogram; Take methyltestosterone control, same method determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:38:41
Neo-Homobreol (M) - Category
Authoritative Data Verified Data
androgens.
Last Update：2022-01-01 11:38:42
Neo-Homobreol (M) - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:38:42
Neo-Homobreol (M) - Methyltestosterone Tablets
Authoritative Data Verified Data
This product contains E. Coli (C20H3002) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about 10 mg of methyltestosterone), add ethanol or chloroform 10mU and stir to dissolve methyltestosterone, filter, and evaporate the filtrate on a water bath, the residue was identified according to the test of item (1) and item (3) under the item of methyltestosterone, and showed the same result.
examination
- Content uniformity take 1 tablet of this product, put it in a 50ml measuring flask, add an appropriate amount of methanol, sonicate to dissolve methyltestosterone, let it cool, dilute to the scale with methanol, shake well, filter, the content of the continued filtrate shall be determined according to the method under the content determination item, and shall comply with the regulations (General rule 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), with ethanol solution (5-100) 500ml as the dissolution medium, the rotation speed is rpm, operate in accordance with the law, after 45 minutes, take the solution filtration, take the filtrate, according to UV-visible spectrophotometry (General rule 0401), at the wavelength of 249nm absorbance measurement; Another methyltestosterone control, precision weighing, plus ethanol solution (5-100) dissolved and quantitatively diluted into each lml containing about Loug solution, the same method to determine, calculate the dissolution of each tablet. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 10mg equivalent to methyltestosterone), put it in a 100ml measuring flask, add the appropriate amount of methanol, ultrasound to dissolve methyltestosterone, cool, dilute to the scale with methanol, shake well, filter, take the filtrate and measure it according to the method under the item of methyltestosterone content determination.
category
Same as methyltestosterone.
specification
5mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:38:43
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Product Name: 17-Methyltestosterone Visit Supplier Webpage Request for quotationCAS: 58-18-4
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 17-methyltestosterone Request for quotation
CAS: 58-18-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 58-18-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
View History
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