Neostigminmethylsulfat
Neostigmine methyl sulfate
CAS: 51-60-5
Molecular Formula: C12H19N2O2.CH3O4S
Neostigminmethylsulfat - Names and Identifiers
Neostigminmethylsulfat - Physico-chemical Properties
| Molecular Formula | C12H19N2O2.CH3O4S |
| Molar Mass | 334.39 |
| Melting Point | 175-177°C(lit.) |
| Water Solubility | 1g/10mL |
| Solubility | H2O: 1g/mL |
| Appearance | powder |
| Color | white |
| Merck | 14,6464 |
| Storage Condition | -20°C |
| Use | For myasthenia gravis, abdominal bloating after surgery and urinary retention |
Neostigminmethylsulfat - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R28 - Very Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | CY1225000 |
| HS Code | 29242990 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann) |
Neostigminmethylsulfat - Reference Information
| introduction | neostigmine can inhibit cholinesterase activity, prevent acetylcholine from hydrolysis, increase the concentration of acetylcholine in the body, and thus strengthen and prolong the effect of acetylcholine. Neostigmine has a strong effect on the smooth muscles of the gastrointestinal tract, bladder and uterus, and has a weak effect on the smooth muscles of the glands, iris and bronchus and the inhibition of the cardiovascular system; the effect on the center is not obvious. |
| pharmacological action | inhibits cholinesterase activity, causes ACh accumulation, and exerts choline-like effect. Nicotinic receptors (N2 receptors) on skeletal muscle motor endplates are directly activated. Strong excitatory effect on skeletal muscle. The smooth muscle of the gastrointestinal tract can promote gastric contraction and increase gastric acid secretion, and promote the peristalsis of the small and large intestine, especially the colon, thereby preventing intestinal relaxation and promoting the downward advancement of intestinal contents. Weak effect on glands, eyes, cardiovascular and bronchial smooth muscle. The effect on the center is weak. |
| indications | for myasthenia gravis for antagonizing the residual muscle relaxant effect of non-depolarizing muscle relaxant at the end of surgery functional intestinal flatulence and urinary retention after surgery. |
| biological activity | Hodostin (Neostigmine methyl sulfate, Syntostigmin, Neostigmeth) is a reversible inhibitor of acetylcholinesterase (AChE) that cannot penetrate the blood-brain barrier and is used to treat myasthenia gravis. |
| use | for myasthenia gravis, postoperative abdominal inflation and urinary retention pharmaceutical raw materials, neostigmine methate is mainly used as anticholinic drugs |
| Production method | Dimethylaminophenol and dimethylcarbamoyl chloride are esterified to obtain neostigmine base, and then methyl bromide is used to form quaternary ammonium salt reaction to obtain bromoneostigmine. If the neosamine base is reacted with dimethyl sulfate to form a quaternary ammonium salt, neosamine methyl sulfate is produced. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | subcutaneous-rat LD50: 0.334 mg/kg; Oral-mouse LD50: 7.5 mg/kg |
| flammability hazard characteristics | combustible, decomposes toxic nitrogen oxides and sulfur oxide gases during combustion |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 19:05:09
