Nicotredole
Nicotredole
CAS: 29876-14-0
Molecular Formula: C16H15N3O
Nicotredole - Names and Identifiers
Nicotredole - Physico-chemical Properties
| Molecular Formula | C16H15N3O |
| Molar Mass | 265.31 |
| Density | 1.0944 (rough estimate) |
| Boling Point | 408.53°C (rough estimate) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6500 (estimate) |
| In vitro study | Nicotredole inhibits prostaglandin synthetase activity in vitro. |
| In vivo study | Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema. Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice. Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively. Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively. Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm 3 ). |
Nicotredole - Reference Information
| biological activity | nicolodole (traptamide) is an orally active anti-inflammatory and analgesic agent. Nicoledole showed a significant anti-inflammatory effect comparable to that of Phenylbutazone. Nicoledole has only weak ulcerogenic activity. |
Last Update：2024-04-09 20:44:15
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