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Nifuroxazide

nifuroxazide

CAS: 965-52-6

Molecular Formula: C12H9N3O5

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Nifuroxazide - Names and Identifiers

Name nifuroxazide
Synonyms Adral
r.c.27-109
Nifurocazide
NIFUROXAZIDE
nifuroxazide
4-hydroxy-2-(5-nitrofurfurylidene)benzohydrazide
(nitro-5'furfurylidene-2')hydroxy-4benzhydrazide
(5-Nitro-2-furfurylidene)(4-hydroxybenzoyl)hydrazine
p-hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide
p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide
4-hydroxy-N'-[(5-nitrofuran-2-yl)methylidene]benzohydrazide
4-hydroxy-benzoicaci((5-nitro-2-furanyl)methylene)hydrazide
4-Hydroxybenzoic Acid 2-[(5-Nitro-2-furanyl)methylene]hydrazide
4-hydroxy-N'-[(1E)-(5-nitrofuran-2-yl)methylidene]benzohydrazide
CAS 965-52-6
EINECS 213-522-0
InChI InChI=1/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+

Nifuroxazide - Physico-chemical Properties

Molecular FormulaC12H9N3O5
Molar Mass275.22
Density1.3877 (rough estimate)
Melting Point281-283°C
Boling Point418.17°C (rough estimate)
Solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Appearanceneat
ColorYellow
BRN4264976
pKa8.36±0.15(Predicted)
Storage ConditionInert atmosphere,2-8°C
Refractive Index1.5700 (estimate)
In vitro studyNifuroxazide is a nitrofuran compound inhibitor that inhibits the signal transduction of the STAT transcription factor. Nifuroxazide blocks constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, thereby reducing myeloma cell viability without affecting normal peripheral blood mononuclear cells. Nifuroxazide was able to reduce the tyrosine phosphorylation of Jak and TYK2 without an effect on EGF receptor tyrosine kinase or Src kinase, indicating the relative specificity of Nifuroxazide for Jak2 and tyk2. Nifuroxazide did not inhibit Akt or MAPK phosphorylation. Nifuroxazide Inhibits Constitutive phosphorylation of STAT3 in MM cells by reducing Jak kinase autophosphorylation and leads to downregulation of target gene Mcl-1 of STAT3. Nifuroxazide caused a decrease in the viability of primary myeloma cells and myeloma cell lines containing STAT3 activation, but did not affect normal peripheral blood mononuclear cells. While bone marrow stromal cells provide a survival signal for myeloma cells, nifuroxazide blocks this survival advantage. Relative to the interaction of STAT3 with other cellular pathways, nifuroxazide in combination with histone deacetylase inhibitor depsipeptide or MEK inhibitor UO126 will show greater cytotoxicity.
In vivo study Compared with the vehicle group, treatment with Nifuroxazide could inhibit tumor growth and tumor weight in a dose-dependent manner, with the inhibition rate of tumor volumes being 43.0% and 62.1% at 25 mg/kg and 50 mg/kg, respectively. It is also shown that Nifuroxazide significantly inhibits the proliferation of nuclear Ki-67-positive cells and induces apoptosis cells of cleaved caspase-3-positive cells. Besides, it is found that treatment with Nifuroxazide could inhibit the expression of MMP-2, MMP-9 and p-Stat3 in A375 tumor tissues. What’s more, Nifuroxazide inhibits the infiltration of MDSCs into the lung, which might be associated with suppression of distant colonization of tumor cells in B16-F10 melanoma metastasis model.

Nifuroxazide - Risk and Safety

WGK Germany3
RTECSDH2528300
ToxicityLD50 intraperitoneal in mouse: 1gm/kg

Nifuroxazide - Reference Information

biological activity Nifuroxazide is a cell-permeable, orally effective nitrofuran antidiarrheal, effectively inhibits the activation of STAT1/3/5 transcriptional activity in cells with IC50 of 3 μm.
TargetValue
Use prevention and treatment of Escherichia coli, salmonella, Pasteurella (including reectococcus), Aerobacter, Proteus, intestinal or urinary system diseases caused by necrosis bacteria and Staphylococcus. Can effectively prevent diarrhea, promote animal feed
Last Update：2024-04-10 22:29:15
Nifuroxazide
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: nifuroxazide Request for quotation
CAS: 965-52-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Nifruoxazide Visit Supplier Webpage Request for quotation
CAS: 965-52-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Wuhan Boye Science And Technology Development Co., Ltd.
Product Name: Nifuroxazide Request for quotation
CAS: 965-52-6
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
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Nifuroxazide
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