Molecular Formula | C14H14O4 |
Molar Mass | 246.26 |
Density | 1.334±0.06 g/cm3(Predicted) |
Melting Point | 186.5-187 °C(Solv: benzene (71-43-2)) |
Boling Point | 434.0±45.0 °C(Predicted) |
Specific Rotation(α) | -22.4.-19.4 (CHCl3) |
pKa | 14.34±0.29(Predicted) |
Storage Condition | 2-8℃ |
Reference Show more | 1. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or |
biological activity | Nodakenetin (NANI) is a plant coumarin isolated from Angelica decursiva, which can inhibit alpha-glucosidase, PTP1B, rat lens aldose reduction (RLAR), AChE, BChE, and β-site amyloid pre-cursor protein cleaving enzyme1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2 and promotes mitochondrial apoptosis. Nodakenetin has anti-tumor activity. |
Target | Value |