Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine
N(alpha)-boc-N(im)-2,4-dinitrophenyl-L-histidine
CAS: 25024-53-7
Molecular Formula: C17H19N5O8
Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine - Names and Identifiers
| Name | N(alpha)-boc-N(im)-2,4-dinitrophenyl-L-histidine |
| Synonyms | Boc-His(Dnp) Boc-His(DNP)-OH BOC-HIS(DNP)-OH BOC-L-HIS(DNP)-OH Boc-His(Dnp)-OH·IPA Boc-His(DNP)-OH*IPA BOC-L-HISTIDINE (DNP) Boc-His(Dnp)-OH.isopropanol BOC-L-DINITROPHENYL HISTIDINE na-T-boc-N-im-dnp-L-histidine N-α-Boc-N-im-dinitrophenyl-L-histidine Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine N(alpha)-boc-N(im)-2,4-dinitrophenyl-L-histidine N(alpha)-boc-N((im))-2,4-dinitrophenyl -L-histidine N-(tert-butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine N-(tert-butoxycarbonyl)-1-(2,4-dinitrophenyl)-D-histidine N-(tert-Butoxycarbonyl)-N(im)-2,4-dinitrophenyl-L-histidine |
| CAS | 25024-53-7 |
| EINECS | 246-569-0 |
| InChI | InChI=1/C17H19N5O8/c1-17(2,3)30-16(25)19-12(15(23)24)6-10-8-20(9-18-10)13-5-4-11(21(26)27)7-14(13)22(28)29/h4-5,7-9,12H,6H2,1-3H3,(H,19,25)(H,23,24)/t12-/m1/s1 |
Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine - Physico-chemical Properties
| Molecular Formula | C17H19N5O8 |
| Molar Mass | 421.36 |
| Density | 1.49g/cm3 |
| Melting Point | 98-100°C (dec.) |
| Boling Point | 663.2°C at 760 mmHg |
| Flash Point | 354.9°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 1.72E-18mmHg at 25°C |
| Appearance | Solid |
| BRN | 771922 |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.638 |
| MDL | MFCD00065966 |
Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine - Reference
| Reference Show more | 1. [IF=9.776] Qi Shang et al.Dual cancer stem cell manipulation to enhance phototherapy against tumor progression and metastasis.J Control Release. 2021 Dec;340:282 |
Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | N-Boc-1-(2, 4-dinitrophenyl)-L-histidine, as a typical derivative of L-histidine, has received more and more attention in the field of pharmaceutical and chemical industry. |
| Preparation | Using 2, 4-dinitrophenyl-L-histidine as the starting material, the target compound N-(tert-butoxycarbonyl)-1-(2, 4-dinitrophenyl)-L-histidine was prepared by amino protection reaction with ditert-butyl dicarbonate. Fig. 1 experimental operation of synthesis reaction formula of N-(tert-butoxycarbonyl)-1-(2, 4-dinitrophenyl)-L-histidine: 2,4-dinitrophenyl-L-histidine is dissolved in 100mL of sodium hydroxide aqueous solution, 200mL of tetrahydrofuran and 250g of ditert-butyl dicarbonate are sequentially added, the pH value is controlled to 8-9, and after 12h of reaction, ethyl acetate is extracted twice, 500mL each time; HCI is used to acidify the aqueous phase to a pH value of 1-2, and ethyl acetate is used to extract the product 3 times, 500mL each time. The ester layers are combined and washed twice with saturated brine, 200 m1. Dry with anhydrous sodium sulfate for 12h, filter, concentrate and crystallize, and dry at 40-50 ℃ to obtain N-(tert-butoxycarbonyl)-1-(2, 4-dinitrophenyl)-L-histidine. |
Last Update：2024-04-09 20:52:54
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