O-Desmethylvenlafaxine
O-Desmethylvenlafaxine
CAS: 93413-62-8
Molecular Formula: C16H25NO2
O-Desmethylvenlafaxine - Names and Identifiers
| Name | O-Desmethylvenlafaxine |
| Synonyms | Desmethylvenlafaxine O-Desmethylvenlafaxine DL-O-Desmethylvenlafaxin O-DESMETHYL VENLAFAXINE-D10 Desvenlafaxine(O-Desnethylvenfaxine) 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol 1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol 4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol |
| CAS | 93413-62-8 |
| EINECS | 700-516-2 |
| InChI | InChI=1/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 |
| InChIKey | KYYIDSXMWOZKMP-UHFFFAOYSA-N |
O-Desmethylvenlafaxine - Physico-chemical Properties
| Molecular Formula | C16H25NO2 |
| Molar Mass | 263.38 |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Melting Point | 208-213°C |
| Boling Point | 403.8±25.0 °C(Predicted) |
| Flash Point | 9℃ |
| Vapor Presure | 3.03E-07mmHg at 25°C |
| Appearance | neat |
| pKa | 10.04±0.26(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.573 |
| In vitro study | Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and an active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine showed a weak affinity for the human dopamine (DA) transporter (62% inhibition at 100 μm). Desvenlafaxine inhibition [Desvenlafaxine Succinate has the potential to inhibit CYP2D6, which may lead to an increase in the concentration of drug metabolism through this pathway. Desvenlafaxine Succinate may also induce CYP3A4, which may affect the metabolism of drugs by this enzyme. |
| In vivo study | Desvenlafaxine rapidly penetrated the brain and hypothalamus of male rats. Desvenlafaxine significantly increased extracellular NE levels compared to basal NE levels in the hypothalamus of male rats, but did not affect DA levels by microdialysis. Desvenlafaxine showed a linear dose-proportional pharmacokinetic single dose distribution over the dose range of 100 to 600 mg/kg. The full bioavailability of the oral dosage form is 80.5%. |
O-Desmethylvenlafaxine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R36 - Irritating to the eyes |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GV8872620 |
| HS Code | 29225090 |
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Product Name: Desvenlafaxine Visit Supplier Webpage Request for quotationCAS: 93413-62-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: O-Desmethylvenlafaxine Visit Supplier Webpage Request for quotationCAS: 93413-62-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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