OP-1074
OP-1074
CAS: 1443752-76-8
Molecular Formula: C29H31NO4
OP-1074 - Names and Identifiers
| Name | OP-1074 |
| Synonyms | OP-1074 |
| CAS | 1443752-76-8 |
OP-1074 - Physico-chemical Properties
| Molecular Formula | C29H31NO4 |
| Molar Mass | 457.56 |
OP-1074 - References
| biological activity | OP-1074, pure anti-estrogen, is a selective ER degradation agent (PA-SERD), it has specific antiestrogenic activity against ERα and ERβ, and can inhibit the transcriptional activity of 17 β-estradiol (E2)-stimulation with IC50 of 1.6 and 3.2 nM, respectively. |
| Cell Line: | MCF-7 cells, CAMA-1 cells MCF-7 cells, CAMA-1 cells |
| Concentration: | 0 nM, 10 nM,100 nM 100 nM |
| Incubation Time: | 24 hours 24 hours |
| Result: | Inhibited breast cancer cell proliferation. Downregulated ERα protein expression. |
Last Update：2024-04-09 15:16:58
