OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE
CAS: 80277-40-3
Molecular Formula: C9H4F3NO
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE - Names and Identifiers
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE - Physico-chemical Properties
| Molecular Formula | C9H4F3NO |
| Molar Mass | 199.13 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE - Risk and Safety
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3276 |
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE - Reference Information
| introduction | oxo-(4-trifluoromethyl-phenyl-acetylcyanide is a pharmaceutical intermediate, which can be prepared by one-step reaction of p-trifluoromethyl benzoyl chloride and cuprous cyanide. |
| use | oxo-4-trifluoromethyl-phenyl-acetylcyanide is a pharmaceutical intermediate, and it has been reported in the literature that it can be used to prepare modulators of dopamine D3 receptors. |
| preparation | p-trifluoromethylbenzoyl chloride (20mmol) is added to the stirred suspension of cuprous cyanide (I)(3.59g,40mmol) in anhydrous acetonitrile (70mL) under argon atmosphere. After refluxing for 2-4 hours, the resulting clarified solution was cooled to room temperature and concentrated in vacuum. The residue was washed with ether or ethyl acetate, filtered and vacuum concentrated again. After additional distillation, the desired product oxo-(4-trifluoromethyl-phenyl-acetylcyanide) is obtained. Colorless oil with a yield of 59%. |
Last Update：2024-04-09 19:05:04
Supplier List
Spot supply
Product Name: Oxo-(4-trifluoromethyl-phenyl)acetonitrile Visit Supplier Webpage Request for quotationCAS: 80277-40-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE Visit Supplier Webpage Request for quotation
CAS: 80277-40-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 80277-40-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Oxo-(4-trifluoromethyl-phenyl)acetonitrile Visit Supplier Webpage Request for quotationCAS: 80277-40-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE Visit Supplier Webpage Request for quotation
CAS: 80277-40-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 80277-40-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
OXO-(4-TRIFLUOROMETHYL-PHENYL)-ACETONITRILE
GNF 5
C.I. Acid Blue 168
4-(4-ETHYLTHIOPHENYL)-4-OXOBUTYRIC ACID 95%
Tetraphenyl phosphonium bromide
2,4-DICHLOROTHIAZOLE
Dimethylethoxysilane
trans,cis-2,6-Nonadienal
1-Amino-4-(2-hydroxyethyl)piperazine
Octane, 2-iodo-1-isothiocyanato-
GNF 5
C.I. Acid Blue 168
4-(4-ETHYLTHIOPHENYL)-4-OXOBUTYRIC ACID 95%
Tetraphenyl phosphonium bromide
2,4-DICHLOROTHIAZOLE
Dimethylethoxysilane
trans,cis-2,6-Nonadienal
1-Amino-4-(2-hydroxyethyl)piperazine
Octane, 2-iodo-1-isothiocyanato-