OXOLAMINECITRATE
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
CAS: 1949-20-8
Molecular Formula: C20H27N3O8
OXOLAMINECITRATE - Names and Identifiers
OXOLAMINECITRATE - Physico-chemical Properties
| Molecular Formula | C20H27N3O8 |
| Molar Mass | 437.444 |
| Melting Point | 141-142 °C |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive Oxolamine citrate (SKF-9976 citrate) is an antitussive agent that can be used in studies of respiratory diseases. Oxolamine citrate also showed anti-inflammatory effects. |
| Use | The antitussive drug osoramine tablet has antipyretic, analgesic and anti-inflammatory effects similar to aspirin, and has a strong antagonistic effect on respiratory tract inflammation, it has a significant inhibitory effect on Cough caused by inhalation of irritating gases in animals, and its mechanism of action is to inhibit the receptors of lung and bronchus to be peripheral antitussive, and its clinical therapeutic effect is good. Most of the antitussive drugs commonly used in the current market contain codeine, and codeine is prone to addiction during the long Chemical Book period. The greatest advantage of osoramine citrate is the lack of tolerance and recessive in long-term use. Due to the syrup after taking the pharynx mucosa, can weaken the stimulation of the mucosa, sweet, welcomed by the children, in the treatment of Cough, syrup was better than tablets. Cough syrup on the market is mainly based on traditional Chinese medicine. The utilization rate of traditional Chinese medicine syrup is low, and the preparation process is cumbersome. |
OXOLAMINECITRATE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
OXOLAMINECITRATE - Osoramine syrup and preparation method thereof
patent type:
invention patent
Application (patent) number:
CN200810070488.X
application date:
20080118
Public/Announcement Number:
CN101219109A
Public/announcement date:
20080716
applicant (patent):
Xiamen University
inventor:
National and provincial code:
CN350203
Abstract:
The invention relates to a syrup, especially to an osoramine syrup mainly used for relieving cough and a preparation method thereof. To provide a preparation method of simple, good therapeutic effect, long-term use of non-tolerance and recessive, especially suitable for children taking the preparation method and the preparation method. Its composition and content calculated according to 1000ml are: osoramine 6~10g, citric acid 0.1~0.2g, methylparaben 0.1~0.5g, Gardenia yellow 0.2~2g, orange flavor 1~3ml, sucrose 400 ~ G, the rest is water. Boil water, add sucrose, stir to dissolve, heat to 100 °c, add water to room temperature after filtration, shake to obtain a single syrup; Mix the aqueous solution of oxoramin with the single syrup, then add citric acid, methyl paraben, gardenia yellow and orange flavor, stir to obtain the target product.
Last Update：2024-01-02 23:10:35
OXOLAMINECITRATE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.286 ml | 11.43 ml | 22.86 ml |
| 5 mM | 0.457 ml | 2.286 ml | 4.572 ml |
| 10 mM | 0.229 ml | 1.143 ml | 2.286 ml |
| 5 mM | 0.046 ml | 0.229 ml | 0.457 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Request for quotation
CAS: 1949-20-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1949-20-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
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Product Name: Oxolamine Citrate Visit Supplier Webpage Request for quotationCAS: 1949-20-8
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Mobile: 18021002903
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