Oprea1_276019
AKOS BBS-00004526
CAS: 299166-55-5
Molecular Formula: C7H10N4O
Oprea1_276019 - Names and Identifiers
Oprea1_276019 - Physico-chemical Properties
| Molecular Formula | C7H10N4O |
| Molar Mass | 166.18 |
| Density | 1.413 |
| Storage Condition | 2-8°C |
Oprea1_276019 - Risk and Safety
| Hazard Class | IRRITANT |
Oprea1_276019 - Reference Information
| Application | 1,4,5, 6-tetrahydrocyclopentopyrazole-3-hydrazide is a pharmaceutical intermediate, which can be prepared from cyclopentanone and diethyl oxalate as starting materials, ethyl 6-tetrahydrocyclopentopyrazole-3-carboxylate is reacted with hydrazine hydrate to give 1,4,5, 6-tetrahydrocyclopentopyrazole-3-hydrazide. |
| preparation | with stirring, add 23.8g(0.283mol) cyclopentanone, 42g (0.288mol,1.02eq) diethyl oxalate, 1.02 ml ethanol, a mixture of G (0.288mol, eq) of potassium ethoxide and ML of ethanol was added dropwise to three vials at 21-23 °c. After the dropwise addition was completed, 28ml of concentrated hydrochloric acid was added at room temperature to adjust the PH to 1. After the reaction was stirred for 20 minutes while keeping the temperature at not more than 40 ° C., the reaction solution was cooled to room temperature, and 21.8g (0.37mol,1.3eq) of 85% hydrazine hydrate was slowly added dropwise. White smoke was generated during the dropwise addition, and the reaction was stirred for 1.5 hours. The progress of the reaction was monitored by thin layer chromatography, and the reaction was terminated after the raw materials were completely consumed. 150mL ml of pure water was added to the reaction flask and evaporated to dryness to obtain a bright yellow thick product, which was cooled to room temperature, and sodium bicarbonate solution was added in portions, followed by stirring at room temperature for 10 minutes. The filter cake was washed with cold water and dried at 65 ° C. To obtain 38.1g of Ethyl 1,4,5, 6-tetrahydrocyclopentopyrazole-3-carboxylate as a yellow solid. The yield for this step was 74.7%. Then 1,4,5, 6-tetrahydrocyclopentopyrazol-3-hydrazide (970mg,5mmol) and hydrazine (1.34g,35mmol) in ethanol (10ml) heat to reflux for 1 day. At the end of this stage, the ethanol was evaporated and the precipitate was collected by filtration and washed with ethyl acetate and water to give the product. |
Last Update：2024-04-09 20:52:54
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Product Name: AKOS BBS-00004526 Visit Supplier Webpage Request for quotation
CAS: 299166-55-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 299166-55-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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