Oxbendazole

Oxbendazole - Names and Identifiers

Name	Oxbendazole
Synonyms	Oxbendazole oxibendazole Oxybendazole oxibendazole Solution, 100ppm Methyl 5-propoxybenzimidazole-2-carbamate 5-Propoxy-2-(carbomethoxyamino)benzimidazole Methyl (5-n-propoxy-2-benzimidazolyl)carbamate methyl (6-propoxy-1H-benzimidazol-2-yl)carbamate methyl (5-propoxy-1h-benzimidazol-2-yl)carbamate Methyl N-(5-propoxy-3H-benzoiMidazol-2-yl)carbaMate methyl N-(5-propoxy-3H-benzoimidazol-2-yl)carbamate 5-Propoxy-1H-benzimidazole-2-carbamic acid methyl ester (5-Pmpoxy-1H- benzimidazol-2-y1)carbamic acid methyl ester N-(6-propoxy-1H-benzimidazol-2-yl)-carbamic acid methyl ester
CAS	20559-55-1
EINECS	243-877-7
InChI	InChI=1/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

Oxbendazole - Physico-chemical Properties

Molecular Formula	C12H15N3O3
Molar Mass	249.27
Density	1.301±0.06 g/cm3(Predicted)
Melting Point	230-231°C
Solubility	DMSO : 1 mg/mL ( ultrasonic)H2O : 0.1 mg/mL (ultrasonic and warming and heat to 80°C)
Appearance	neat
Color	Off-White
Merck	14,6936
pKa	10.60±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.634
Physical and Chemical Properties	melting point 230-231°C
Use	Used as anthelmintic
In vivo study	Oxibendazole treatment significantly reduced the specific gravity of positive foals. Oxibendazole significantly reduced the proportion of positive foals in 7/6 farms (86%). In horses, Oxibendazole reduced the number of round worm eggs per gram (EPG), but the reduction was only 82%, with an 89% upper confidence limit. In adult Ascaris suum, Oxibendazole causes collapse of the labial papilla, oral cuticle, pharyngeal prolapse, erosive degeneration of epithelial cells and microvilli, changes that may impair digestion and absorption of nutrients, and cause cell autolysis, leading to the death of the worm. In dogs and cats, Oxibendazole reduced fecal worm egg count (EPG) by 97.6 percent for Toxocara canis, 95.7 percent for Trichuris vulpis, 94.6 percent for Ancylostoma caninum, and 100 percent for Toxascaris leonine. In horses, Oxibendazole can only be detected in plasma 0.5 and 1.0 hours after administration, with a mean maximum plasma concentration of 0.008 mg/ml. Oxibendazole was detected in feces between 12 and 72 hours after dosing, with the highest dry fecal concentration detected at 24 hours.

Oxbendazole - Risk and Safety

WGK Germany	3
RTECS	FD0835000
HS Code	29339900

Oxbendazole - Introduction

Oxibendazole, also known as SK&F-30310, SKF-30310, is a DNA polymerase inhibitor potentially for the treatment of helminth intestinal infections. Oxibendazole is laso used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets. It is usually white to yellowish in appearance.

Last Update：2022-10-16 17:14:50