P-AMINOPROPIOPHENONE
4'-Aminopropiophenone
CAS: 70-69-9
Molecular Formula: C9H11NO
P-AMINOPROPIOPHENONE - Names and Identifiers
| Name | 4'-Aminopropiophenone |
| Synonyms | NSC 3187 NSC 404994 P-AMINOPROPIOPHENONE 4-Aminopropiophenone p-Aminopropiophenone 4'-Aminopropiophenone para-Aminopropiophenone P-AMINOPHENYL ETHYL KETONE 1-(4-aminophenyl)-1-propanon 4'-Aminopropiophenone hydrochloride salt 4'-Aminopropiophenone1-(4-Aminophenyl)-1-propanone |
| CAS | 70-69-9 |
| EINECS | 200-742-7 |
| InChI | InChI=1/C9H11NO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3 |
P-AMINOPROPIOPHENONE - Physico-chemical Properties
| Molecular Formula | C9H11NO |
| Molar Mass | 149.19 |
| Density | 1.067±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 135-140 °C |
| Boling Point | 270.27°C (rough estimate) |
| Flash Point | 138.7°C |
| Water Solubility | 352.1mg/L(37.5 ºC) |
| Vapor Presure | 0.000805mmHg at 25°C |
| Color | Needles from water |
| pKa | 2.86±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5279 (estimate) |
P-AMINOPROPIOPHENONE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | 2811 |
| HS Code | 29223990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in male, female mice (mg/kg): 145, 200 i.v.; in female mice, guinea pigs, rats, male rats (mg/kg): >5000, 1020, 223.7, 475 orally (Scawin) |
P-AMINOPROPIOPHENONE - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | 4-aminopropiophenone is a primary aromatic amine compound. Primary aromatic amines are very important intermediates in dyes, pigments, materials, pesticides, pharmaceuticals and other industries. |
| preparation | to a dry reaction tube was added 4-hydroxyphenylacetone (224 mg, 1.5 mmol), naO H(60 mg, 1.5 mmol), 2-chloropropionamide (321 mg, 3.0mmol), dioxane (3 ml) and DMPU(1ml), reaction at 60 ° C for 4 hours, additional NaOH(60 m g, 1.5 mmol), reaction at 100 ° C for 24 hours, adding 10ml of water, dichloromethane (3 × 25 ml) extraction, the organic phase was washed with saturated brine (2 × 20 ml), dried with anhydrous sodium sulfate dried, filtered, and rotary Distilled. Rapid silica gel column chromatography (eluent: petroleum Ether/ethyl acetate = 5/1) to give the product 4-aminopropiophenone as a yellow solid. |
| Use | 4-aminopropiophenone is a primary aromatic amine compound that can be used as an intermediate in organic synthesis. |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 177 mg/kg; Oral-mouse LD50: 168 mg/kg |
| flammability hazard characteristics | flammable; Toxic NOx smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:21:28
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