| Molecular Formula | C203H331N63O53S1 |
| Molar Mass | 4534.26 |
| Appearance | White to off-white solid |
| Storage Condition | -20°C |
| In vitro study | PACAP 1-38 has potent, sustained activation of sympathetic NPY and catecholamine production. It is a pleiotropic neuropeptide with a variety of biological activities, including activity as neurotransmitters, neuromodulators, neurotrophic factors, and in immune cells, the immune response is regulated by the regulation of MAPK signaling pathway and the activation of NFκB. PACAP 1-38 can significantly prevent renal proximal tubular epithelial cell injury due to the production of proinflammatory factors, inhibition of p38 MAPK and PAC1 and VPAC1 mediated translocation of NF-κB. PACAP38 directly inhibits the growth of myeloma cells, probably by indirectly inhibiting the production of growth factor IL-6 in bone marrow stromal cells, IL-6 of which is activated by the adhesion of myeloma cells. PACAP38 inhibited IL-6 and TNFα release in a dose-dependent manner. |
| In vivo study | PACAP38 can effectively inhibit the expression of light chain induced cytokines and prevent the resulting cell damage in vivo. For some tumors, PACAP38 is also considered to be an autoregulatory factor that activates tumor growth in an autocrine form. |
| WGK Germany | 3 |
| RTECS | TO7345000 |
| biological activity | PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly effective PACAP receptor agonist (Kd = 100 pM), which can stimulate adenylate cyclase and phagocytosis. |
| target | TargetValue PAC1 1.1 nM(Ki) PAC1s 1.7 nM(Ki) PAC1vs 121 nM(Ki) |
| Target | Value |
| PAC1 | 1.1 nM(Ki) |
| PAC1s | 1.7 nM(Ki) |
| PAC1vs | 121 nM(Ki) |
| in vitro study | PACAP 1-38 has effective and sustained activation effect on sympathetic NPY and catecholamine production. It is a multi-effect neuropeptide with a variety of biological activities, including the activity of neurotransmitters, neuromodulators, neurotrophic factors, and in immune cells, through the MAPK signaling pathway and NFκB activation The regulation of the immune response. PACAP 1-38 can significantly prevent renal proximal tubule epithelial cell damage caused by the production of proinflammatory factors and the inhibition of p38 MAPK and PAC1 and VPAC1-mediated NF-κB translocation. PACAP38 directly inhibits the growth of myeloma cells, possibly by indirectly inhibiting the production of growth factor IL-6 in bone marrow stromal cells, IL-6 production can be activated by the adhesion of myeloma cells. PACAP38 can inhibit the release of IL-6 and TNFα in a dose-dependent manner. |
| in vivo research | PACAP38 can effectively inhibit the expression of cytokines induced by light chains and prevent the resulting cell damage. For some tumors, PACAP38 is also considered to be an autoregulatory factor that activates tumor growth in an autocrine form. |