PERFLUOROBUTANESULPHONICACID
Nonafluorobutane-1-sulfonic acid
CAS: 375-73-5
Molecular Formula: CF3(CF2)3SO3H
PERFLUOROBUTANESULPHONICACID - Names and Identifiers
PERFLUOROBUTANESULPHONICACID - Physico-chemical Properties
| Molecular Formula | CF3(CF2)3SO3H |
| Molar Mass | 300.1 |
| Density | 1.811 g/mL at 25 °C (lit.) |
| Boling Point | 112-114 °C/14 mmHg (lit.) |
| Flash Point | >230 °F |
| Storage Condition | 2-8 ℃, argon filled storage |
| Refractive Index | 0 |
| MDL | MFCD01320794 |
PERFLUOROBUTANESULPHONICACID - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R14 - Reacts violently with water R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
PERFLUOROBUTANESULPHONICACID - Study on the application of halothane sulfonyl fluoride reagent in the synthesis of natural products of yellow skin amide and the synthesis of new type of quaternary ammonium salt of perfluorobutyl sulfonic acid
from Wanfang
Author:
Abstract:
clausenamide natural products have good physiological activity, the study found that this kind of natural products have high medicinal research value. Therefore, it is of great significance to provide a novel and effective synthesis strategy. Based on the existing research work in our laboratory, we expect to give a new, efficient and practical synthetic route for the synthesis of clausenamide natural products. As an important synthetic precursor for the construction of clausenamide series of natural products by intramolecular cyclization reaction. N-alkenyl amide (enamide) structural unit is widely present in many natural products with various physiological activities, and it may be the active structural unit of these natural products. In view of the existing problems in the synthesis of enamide, we systematically studied the perfluoroalkyl sulfonyl fluoride-initiated α,β-unsaturated ketoxime Beckmann rearrangement reaction, an improved method for the synthesis of N-alkenyl amides with appreciable yields is proposed. We present a key synthetic precursor (2S,3R)-n-methyl-3-phenyl-n-(E)-Styryl ethylene oxide -2-formamide simple and efficient synthesis path, we improved the traditional synthesis method using Meth-Cohn reaction, through the optimization of the relevant conditions, it is proposed to use a mild hydrogen peroxide/base system to achieve the synthesis of key precursors. The reaction operation is simple and fast, the post-treatment is simple and pollution-free, and has broad industrial application prospects. We have carried out a more detailed investigation on the above synthetic route, and obtained a more satisfactory expected results, which provides a feasible idea for the synthesis of the rich clausenamide natural products. Fluorocarbon surfactants have good chemical and physical stability, excellent surface activity and chemical activity, and are widely used in life, industry and chemical production. Perfluoroalkyl sulfonic acid quaternary ammonium salt active agent because of its excellent performance has always been extremely important research significance. In the study of some related reactions using sulfonyl fluoride reagent, we have unexpectedly obtained a new type of perfluoroalkyl sulfonic acid quaternary ammonium salt product, which uses sulfonyl fluoride reagent and substrate alcohol and organic base (Et3N,DBU) in the mild conditions in the next step to synthesize the corresponding structure of the product, the use of this method is low cost, simple operation steps, greatly enriched the perfluoroalkyl sulfonic acid quaternary ammonium salt synthesis method.
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Key words:
degree level:
MSc
DOI:
CNKI:CDMD:2.1016.253225
Last Update：2024-01-02 23:10:35
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