PF05175157
PF 05175157
CAS: 1301214-47-0
Molecular Formula: C23H27N5O2
PF05175157 - Names and Identifiers
| Name | PF 05175157 |
| Synonyms | CS-2573 PF05175157 PF 05175157 PF-05175157 1-isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one 1'-(2-methyl-1H-1,3-benzodiazole-6-carbonyl)-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidin]-7-one 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one Spiro[5H-indazole-5,4'-piperidin]-7(6H)-one,1,4-dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)- |
| CAS | 1301214-47-0 |
PF05175157 - Physico-chemical Properties
| Molecular Formula | C23H27N5O2 |
| Molar Mass | 405.49 |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Boling Point | 692.0±55.0 °C(Predicted) |
| pKa | 11.47±0.10(Predicted) |
| Storage Condition | -20℃ |
PF05175157 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.466 ml | 12.331 ml | 24.662 ml |
| 5 mM | 0.493 ml | 2.466 ml | 4.932 ml |
| 10 mM | 0.247 ml | 1.233 ml | 2.466 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.493 ml |
Last Update：2024-01-02 23:10:35
PF05175157 - Reference Information
| biological activity | PF-05175157 is a broad-spectrum effective ACC inhibitor for human ACC1, human ACC2, the IC50 of rat ACC1 and rat ACC2 were 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM, respectively. |
| Target | Value |
| rACC1 (Cell-free assay) | 23.5 nM |
| hACC1 (Cell-free assay) | 27.0 nM |
| hACC2 (Cell-free assay) | 33.0 nM |
| rACC2 (Cell-free assay) | 50.4 nM |
Last Update：2024-04-10 22:29:15
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CAS: 1301214-47-0
Tel: 18301782025
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Mobile: 18021002903
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CAS: 1301214-47-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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