Name | 4-Hydroxybenzeneacetamide |
Synonyms | PHPA ATENOLOL IMP A ATENOLOL IMPURITY A LABOTEST-BB LT00848172 4-Hydroxyphenylacetamide 4-HYDROXYPHENYLACETAMIDE 4-Hydroxybenzeneacetamide 4-HYDROXYBENZENEACETAMIDE P-Hydroxy Pheny lacetamide 2-(4-hydroxyphenyl)acetamide 2-(4-HYDROXYPHENYL)ACETAMIDE Para-Hydroxy Phenyl Acetamide 2-(4-HYDROXYPHENYL)-ETHYLAMIDE 4-HYDROXYPHENYLACETAMIDEATENOLOL |
CAS | 17194-82-0 |
EINECS | 241-235-0 |
InChI | InChI=1/C8H9NO2/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4,10H,5H2,(H2,9,11) |
InChIKey | YBPAYPRLUDCSEY-UHFFFAOYSA-N |
Molecular Formula | C8H9NO2 |
Molar Mass | 151.16 |
Density | 1.2023 (rough estimate) |
Melting Point | 176-178 °C (lit.) |
Boling Point | 273.17°C (rough estimate) |
Flash Point | 198.1°C |
Water Solubility | soluble |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 4.22E-07mmHg at 25°C |
Appearance | Crystallization |
Color | Beige |
BRN | 2085984 |
pKa | 9.99±0.26(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.5810 (estimate) |
MDL | MFCD00017145 |
Physical and Chemical Properties | Melting Point 175-178°C water-soluble solution |
Use | Used as pharmaceutical, organic synthesis intermediates |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | AC3851500 |
TSCA | Yes |
HS Code | 29242990 |
Hazard Note | Irritant |
white crystals. The melting point was 175-177 °c.
There are mainly the following methods:
This product is used for the synthesis of ammonia acyl heart, ammonia acyl heart is a B Blocker, clinical for the treatment of hypertension, angina and arrhythmia, also effective for glaucoma.
fiber cardboard drum, lined with plastic bag, net weight 25kg.
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
use | this product is used for synthesis of aminoacylpropanol, which is a β-blocker. it is clinically used to treat hypertension, angina pectoris and arrhythmia, and is also effective for glaucoma. Used as an intermediate in medicine and organic synthesis |
production method | there are mainly the following methods: 1. p-hydroxyphenylacetate ammoniation method. 2. p-hydroxyphenylacetamide was synthesized by p-hydroxyphenylacetonitrile. 3. The p-hydroxyacetophenone method is obtained by interacting with ammonium sulfide. |