PHPA
4-Hydroxybenzeneacetamide
CAS: 17194-82-0
Molecular Formula: C8H9NO2
PHPA - Names and Identifiers
| Name | 4-Hydroxybenzeneacetamide |
| Synonyms | PHPA ATENOLOL IMP A ATENOLOL IMPURITY A LABOTEST-BB LT00848172 4-Hydroxyphenylacetamide 4-HYDROXYPHENYLACETAMIDE 4-Hydroxybenzeneacetamide 4-HYDROXYBENZENEACETAMIDE P-Hydroxy Pheny lacetamide 2-(4-hydroxyphenyl)acetamide 2-(4-HYDROXYPHENYL)ACETAMIDE Para-Hydroxy Phenyl Acetamide 2-(4-HYDROXYPHENYL)-ETHYLAMIDE 4-HYDROXYPHENYLACETAMIDEATENOLOL |
| CAS | 17194-82-0 |
| EINECS | 241-235-0 |
| InChI | InChI=1/C8H9NO2/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4,10H,5H2,(H2,9,11) |
| InChIKey | YBPAYPRLUDCSEY-UHFFFAOYSA-N |
PHPA - Physico-chemical Properties
| Molecular Formula | C8H9NO2 |
| Molar Mass | 151.16 |
| Density | 1.2023 (rough estimate) |
| Melting Point | 176-178 °C (lit.) |
| Boling Point | 273.17°C (rough estimate) |
| Flash Point | 198.1°C |
| Water Solubility | soluble |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 4.22E-07mmHg at 25°C |
| Appearance | Crystallization |
| Color | Beige |
| BRN | 2085984 |
| pKa | 9.99±0.26(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5810 (estimate) |
| MDL | MFCD00017145 |
| Physical and Chemical Properties | Melting Point 175-178°C water-soluble solution |
| Use | Used as pharmaceutical, organic synthesis intermediates |
PHPA - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | AC3851500 |
| TSCA | Yes |
| HS Code | 29242990 |
| Hazard Note | Irritant |
PHPA - Nature
Open Data Verified Data
white crystals. The melting point was 175-177 °c.
Last Update：2024-01-02 23:10:35
PHPA - Preparation Method
Open Data Verified Data
There are mainly the following methods:
- p-hydroxyphenylacetate amidation method.
- p-hydroxyphenylacetamide was synthesized from p-hydroxyphenylacetonitrile by P-aminophenylacetonitrile method.
- p-hydroxyacetophenone method.
Last Update：2022-01-01 10:52:14
PHPA - Introduction
Soluble in water, soluble in ethanol and methanol.
Last Update：2022-10-16 17:14:24
PHPA - Use
Open Data Verified Data
This product is used for the synthesis of ammonia acyl heart, ammonia acyl heart is a B Blocker, clinical for the treatment of hypertension, angina and arrhythmia, also effective for glaucoma.
Last Update：2022-01-01 10:52:13
PHPA - Safety
Open Data Verified Data
fiber cardboard drum, lined with plastic bag, net weight 25kg.
Last Update：2022-01-01 10:52:14
PHPA - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | this product is used for synthesis of aminoacylpropanol, which is a β-blocker. it is clinically used to treat hypertension, angina pectoris and arrhythmia, and is also effective for glaucoma. Used as an intermediate in medicine and organic synthesis |
| production method | there are mainly the following methods: 1. p-hydroxyphenylacetate ammoniation method. 2. p-hydroxyphenylacetamide was synthesized by p-hydroxyphenylacetonitrile. 3. The p-hydroxyacetophenone method is obtained by interacting with ammonium sulfide. |
Last Update：2024-04-09 02:00:07
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Spot supply
Product Name: Atenolol Impurity 1(Atenolol EP Impurity A) Visit Supplier Webpage Request for quotationCAS: 17194-82-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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Product Name: 4-Hydroxybenzeneacetamide Request for quotationCAS: 17194-82-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
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Product Name: 4-Hydroxybenzeneacetamide Request for quotationCAS: 17194-82-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 4-Hydroxybenzeneacetamide Request for quotationCAS: 17194-82-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: 4-Hydroxyphenylacetamide Visit Supplier Webpage Request for quotationCAS: 17194-82-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: p-Hydroxyphenylacetamide Request for quotationCAS: 17194-82-0
Tel: 86-523-87558858,87612088
Email: 184089063@qq.com
yhj@joxbio.com
Mobile: 86-13615177555,15371578585,15370719785
QQ: 184089063
Wechat: sunmytxjs
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