PIPERLONGUMIN
PIPERLONGUMINE
CAS: 20069-09-4
Molecular Formula: C17H19NO5
PIPERLONGUMIN - Names and Identifiers
PIPERLONGUMIN - Physico-chemical Properties
| Molecular Formula | C17H19NO5 |
| Molar Mass | 317.34 |
| Density | 1.223±0.06 g/cm3(Predicted) |
| Melting Point | 124°C |
| Boling Point | 475.6±45.0 °C(Predicted) |
| Solubility | DMSO : ≥ 100 mg/mL (315.12 mM) |
| Appearance | Powder |
| Color | white to beige |
| pKa | -1.88±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| MDL | MFCD00075706 |
| In vitro study | Piperlongumine is a known ROS inducer that induces cell death in pancreatic cancer cells. As A thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. Piperlongumine can also promote autophagy and mediate tumor cell death by inhibiting the Akt/mTOR signaling pathway. |
| In vivo study | Piperlongumine (50 mg/kg I. p.) caused growth inhibition of tumor cells in vivo without altering biochemical, hematological and histopathological parameters. |
PIPERLONGUMIN - Risk and Safety
| WGK Germany | 3 |
| RTECS | UU7785850 |
PIPERLONGUMIN - Reference
| Reference Show more | 1. Jia Guiqing, Wu Xiaoyu, Wang Yutian, etc. High performance liquid chromatographic study of ceramide in sinonovacula constricta [J]. Modern distance education of Chinese medicine in China, 2018, 29 (14):90-93. 2. [IF = 11.878] Li Xinming et al."A fast and specific fluorecent probe for thioredoxin reductase that works via disculide bond cleavage. Nat Commun. 2019 Jun;10(1):1-12 3. [IF = 3.159] Wu Ye et al."Piperlongumine attenuates vascular remodeling in hypoxic pulmonary hypertension by regulating autophagy."J Cardiol. 2021 Sep;: 4. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710 |
PIPERLONGUMIN - Reference Information
| biological activity | Piperlongumine (PPLGM, Piplartine), a natural alkaloid found in the Piperaceae plant sinonovacula constricta, can increase reactive oxygen species (ROS) levels and selectively kill cancer cells. It is also a direct inhibitor of TrxR1, with inhibitory activity against gastric cancer; A novel CRM1 inhibitor; Inhibiting PI3K/Akt/mTOR in human breast cancer cells. |
| Target | Value |
Last Update：2024-04-09 02:00:12
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Product Name: PIPERLONGUMINE Visit Supplier Webpage Request for quotationCAS: 20069-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Piperlongumine Visit Supplier Webpage Request for quotationCAS: 20069-09-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: PIPERLONGUMINE Visit Supplier Webpage Request for quotationCAS: 20069-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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