PIZOTHIFENUM
Pizotifen
CAS: 15574-96-6
Molecular Formula: C19H21NS
PIZOTHIFENUM - Names and Identifiers
| Name | Pizotifen |
| Synonyms | BC 105 Pizotifen PIZOTIFEN Pizotylene Sanomigran Sandomigran Pizotifenum PIZOTHIFENUM 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) THIOPHENE 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine |
| CAS | 15574-96-6 |
| EINECS | 239-632-9 |
| InChI | InChI=1/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3 |
PIZOTHIFENUM - Physico-chemical Properties
| Molecular Formula | C19H21NS |
| Molar Mass | 295.44 |
| Density | 1.164±0.06 g/cm3(Predicted) |
| Melting Point | 140-142°C |
| Boling Point | 436.7±45.0 °C(Predicted) |
| Flash Point | 217.9°C |
| Solubility | DMSO: ≥8mg/mL |
| Vapor Presure | 7.92E-08mmHg at 25°C |
| Appearance | powder |
| Color | White to Off-White |
| Merck | 14,7515 |
| pKa | pKa 6.95 (Uncertain) |
| Storage Condition | room temp |
| Refractive Index | 1.63 |
| Physical and Chemical Properties | White needle-like crystals, odorless, bitter. Melting point 147.5-151.5 °c. Soluble in ethanol, chloroform and other organic solvents or acid solution, insoluble in water. 2-chloromethylthiophene was synthesized by multi-step reaction. For analgesics. Mainly for the treatment of typical and atypical migraine, can also be used for chronic urticaria, atrial and ventricular premature beat. |
| Use | Used as an anti-migraine drug |
PIZOTHIFENUM - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R63 - Possible risk of harm to the unborn child |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| RTECS | TM7165000 |
PIZOTHIFENUM - Standard
Authoritative Data Verified Data
This product is 1-methyl -4-[9, 10-dihydrobenzo [4,5]-cycloheptrieno [1,2-6]-thiophene + subunit]-piperidine. Calculated as dried product, the content of C19H21NS shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
PIZOTHIFENUM - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in chloroform, slightly soluble in ethanol, insoluble in water.
melting point
The melting point of this product (General 0612) is 147~152°C.
absorption coefficient
take this product, precision weighing, and hydrochloric acid solution (0.9-1000) dissolved and quantitatively diluted into about 10ug solution per lml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 582), and the absorption coefficient was 618.
Last Update：2022-01-01 13:34:32
PIZOTHIFENUM - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 1 drop of sulfuric acid, that is orange red, add water 1ml, orange red will disappear.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 242).
- take about 5mg of this product, according to the oxygen flask combustion method (General rule 0703) for organic destruction, with 5% sodium hydroxide solution 5ml and concentrated hydrogen peroxide solution 1 ml as absorption liquid, after complete combustion, the solution was acidified with dilute hydrochloric acid to show the identification reaction of sulfate (General rule 0301).
Last Update：2022-01-01 13:34:32
PIZOTHIFENUM - Exam
Authoritative Data Verified Data
Related substances
take this product, add ethanol to dissolve and make a solution containing lOmg per lml, as a test solution; Take the appropriate amount of precision, quantitative dilution with ethanol was made to contain 0.10 mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-acetic acid-water (4:1:5) for the developer, expand, dry, set iodine vapor color. If the test solution shows impurity spots, the color should not be deeper compared with the main spots of the control solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 13:34:33
PIZOTHIFENUM - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 10ml dissolved, add crystal violet indicator liquid 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 29.54mg of C19H21NS.
Last Update：2022-01-01 13:34:33
PIZOTHIFENUM - Category
Authoritative Data Verified Data
anti-migraine drugs.
Last Update：2022-01-01 13:34:33
PIZOTHIFENUM - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:34:34
PIZOTHIFENUM - Bensaidingpian
Authoritative Data Verified Data
This product contains 90.0% ~ 110.0% of the labeled amount of benzene (C19H21NS).
trait
This product is sugar-coated tablets, White after removing the coating.
identification
take this product, remove the coating, dilute, weigh an appropriate amount (equivalent to 20mg of phenylidine), add chloroform 20ml, shake to dissolve the phenylidine, separate the chloroform layer, after filtration, the filtrate was evaporated to dryness, and the residue showed the same reaction according to the tests of identification (1) and (3) under the item of benzothiazide.
examination
- Content uniformity take 1 tablet of this product, put it in the mortar, grind it, use O.Olmol/L hydrochloric acid solution (about 40ml) was triturated and transferred to a 50ml measuring flask. The Olmol/L hydrochloric acid solution is diluted to the scale, shaken well, filtered, and the filtrate is taken. The Content shall be determined according to the method under the content determination item, and shall comply with the regulations (General rule 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 third method), with hydrochloric acid solution (9-1000) 100ml as the dissolution medium, the rotation speed is 75 rpm, operate according to law, after 45 minutes, take 10ml of the solution, filter, take the continued filtrate as the test solution; Take the additional reference substance, precision weighing, the dissolution medium was added to dissolve and quantitatively dilute to prepare a solution containing about 5ug per 1 ml as a reference solution. The absorbance of each of the above two Solutions was measured at a wavelength of 0401 Mn by ultraviolet-visible spectrophotometry (general), and the elution amount of each tablet was calculated. The limit is 7 = 0% of the labeled amount and shall be in accordance with the regulations.
- others should be in accordance with the relevant provisions under the item of tablets (General rule OlOl).
Content determination
Take 20 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to 5mg ), put it in a 100ml measuring flask, add O.Olmol/L hydrochloric acid solution (70ml), fully shake to dissolve meperidine, dilute with 0.01mol/L hydrochloric acid solution to the scale, shake well, filter, and take 10ml of continued filtrate with precision, in a 50ml measuring flask, use O.Olmol/L hydrochloric acid solution is diluted to the scale, shake well, according to UV-visible spectrophotometry (General 0401 ), absorbance is measured at the wavelength of 230nm, according to the absorption coefficient of C19H21NS is 600, that's right.
category
Same as fenthiazide.
specification
0.5mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:34:35
PIZOTHIFENUM - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Antihistamines | Phenazeidine, also known as Xindumean and Phenazeidine malate, is a chemically synthesized antihistamines with a chemical structure similar to serheptidine and amitriptyline. It has strong anti-serotonin and antihistamine effects and weak anti-acetylcholine effects. It is one of the commonly used drugs to prevent migraine. This product also inhibits the pain-causing effect of bradykinin (BK) on peripheral nerves and sedative and antidepressant effects. This product can reduce the tolerance to ethanol and strengthen the effects of tranquilizers, sedatives and tricyclic antidepressants. Clinically, it is mainly used for typical and atypical migraine, which can relieve symptoms, reduce the number and duration of attacks, and has a significant effect, but it has no immediate relief effect on acute migraine attacks. It can also be used for erythematous limb pain, Angioedema, chronic urticaria, skin scratches, etc. It is also reported that phenazidine can be used for diarrhea caused by carcinoid syndrome, facial flushing, carotid artery pain, pruritus caused by hypercythemia. [usage and dosage]: tablets: 0.5mg per tablet. Adults take 0.5~1mg orally, 1~3 times a day. In order to reduce the side effects of drowsiness, 0.5mg per night on the 1st to 3rd days, 0.5mg per day at noon and mg per night on the 4th to 6th days, and 0.5mg per day at morning, noon and night on the 7th. If the disease is basically controlled, it can be reduced as appropriate, and 0.5mg per week to an appropriate maintenance amount. The dosage is adjusted according to individual needs. Generally, the effect is only after 2 weeks of taking the medicine. Most of the taking time is 4-6 months, and it will be used after 6 months of taking the medicine to 3-4 weeks after stopping the medicine. This product can be used for patients with atrial and ventricular premature contractions at a dose of 0.5mg 3 times a day. |
| medication instructions | (1) this product is less toxic and can be taken for a long time; Generally, after taking the medicine continuously for half a year, the effect after stopping the medicine can be suspended for half a month to January to observe the effect after stopping the medicine, and the accumulation of the medicine in the body can be avoided. (2) Long-term use should pay attention to hemogram changes. (3) phenazidine should not be combined with monoamine oxidase inhibitors. |
| application attention | (1) this product can cause drowsiness, fatigue, appetite gain, weight gain, and occasionally cause nausea, dizziness, redness of face, muscle pain, etc.: it is generally common within 1-2 weeks after starting to take medicine, and can gradually reduce or disappear after continuing to take medicine. (2) Do not use it for patients with angle-closure glaucoma or prostatic hypertrophy and urinary occlusion. (3) motor vehicle drivers and high-altitude operators should use phenazidine with caution according to the doctor's advice. |
| adverse reactions | 1. lethargy and hyperappetite: lethargy is common within 1~2 weeks after starting taking the medicine, it can gradually reduce or disappear after continuing to take the medicine, and the weight gradually stabilizes after taking the medicine for 6 months. Therefore, drivers and air operators use it with caution. 2. Other side effects: muscle soreness or painful spasm, restless legs, fluid retention, mild headache, dizziness, facial flushing, decreased libido, aggravated seizures, dreaminess, palpitations, rash, menstrual disorders, Insomnia and leukopenia, etc. 3. Anticholinergic effect: Therefore, it is forbidden for glaucoma, prostatic hypertrophy and pregnant women. In addition, long-term use of phenazidine should pay attention to hemogram changes. |
| use | as an anti-migraine drug |
Last Update：2024-04-09 21:04:16
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