PROPIONIC
Propionic anhydride
CAS: 123-62-6
Molecular Formula: C6H10O3
PROPIONIC - Names and Identifiers
| Name | Propionic anhydride |
| Synonyms | propionic Propionyl oxide Propinoicanhydride propanoic anhydride Propionic anhydride PROPANOIC ANHYDRIDE PROPIONIC ANHYDRIDE Propionic Anhydried propionicacidanhydride Propionic acid anhydride Propanoic acid,1,1'-anhydride propanoic acid 1-oxopropyl ester |
| CAS | 123-62-6 |
| EINECS | 204-638-2 |
| InChI | InChI=1/C6H10O3/c1-3-5(7)9-6(8)4-2/h3-4H2,1-2H3 |
PROPIONIC - Physico-chemical Properties
| Molecular Formula | C6H10O3 |
| Molar Mass | 130.14 |
| Density | 1.015g/mLat 25°C(lit.) |
| Melting Point | -42 °C |
| Boling Point | 167°C(lit.) |
| Flash Point | 165°F |
| Water Solubility | hydrolyses |
| Solubility | H2O: decomposes (when in contact with water) |
| Vapor Presure | 10 mm Hg ( 57.7 °C) |
| Vapor Density | 4.5 (vs air) |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| Merck | 14,7826 |
| BRN | 507066 |
| PH | 2.5 (100g/l, H2O, 20℃)(calculated on the free acid) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, water, moisture, most common metals, active halogen compounds, ammonia, amines. |
| Sensitive | Moisture Sensitive |
| Explosive Limit | 1.3-9.5%(V) |
| Refractive Index | n20/D 1.404(lit.) |
| Physical and Chemical Properties | Appearance and properties colorless liquid with irritating odor |
| Use | Mainly used as esterifying agent and nitration or sulfonation of dehydrating agent, also used in the preparation of alkyd resin, dyes and drugs; Used as esterifying agent, dehydrating agent and used in the manufacture of dyes and pharmaceuticals, perfumes |
PROPIONIC - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2496 8/PG 3 |
| WGK Germany | 1 |
| RTECS | UF9100000 |
| TSCA | Yes |
| HS Code | 2915 90 70 |
| Hazard Note | Corrosive/Moisture Sensitive |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 2.36 g/kg (Smyth) |
PROPIONIC - Upstream Downstream Industry
| Downstream Products | erythromycin estolate |
PROPIONIC - Reference Information
| LogP | 0.33 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | propionic anhydride is used as a propionylating agent in the manufacture of medicines, fragrances and special esters, in the pharmaceutical industry, it is used to produce horosamycin propionate (antibiotics), testosterone propionate (male hormone deficiency), oxymethandrosterone propionate (anticancer drug), and chlordimethasone (adrenal cortex). Hormones) and betamethasone dipropionate (adrenal cortex hormone), etc. It is also used as a dehydrating agent for nitration and sulfonation reactions in organic synthesis, and is used to make alkyd resins and dyes. It is mainly used as an esterifying agent and a dehydrating agent for nitrification or sulfonation, and is also used to make alkyd resins, dyes and drugs. As a propionylating agent, it is used for medicine, fragrances and special esters (such as propionate Cellulose) production in medicine can produce the antibiotic drug ceramicin propionate, testosterone propionate for the treatment of male hormone deficiency, anticancer drugs hydroxymethoandrosterone propionate, adrenal cortex hormones such as chlordimethasone propionate and betamethasone dipropionate, etc. propionic anhydride is used as a propionylating agent for the production of medicines, fragrances and special esters (such as cellulose propionate). In medicine, it can be used to prepare the anti-biotics drug grosamycin propionate propionate for the treatment of male hormone deficiency Testosterone propionate, anticancer drug hydroxymethoandrosterone propionate, adrenocortical hormone chlordimethasone propionate and betamisone dipropionate, etc. |
| production method | obtained by heating and dehydration of propionic acid at 235 ℃ and 8 × 105Pa. It can also be heated and refluxed by sodium propionyl chloride for 4 hours, and then distilled and fractionated to collect the 165-169 ℃ fraction as propionic anhydride. |
| category | corroded articles |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 2360 mg/kg |
| stimulation data | skin-rabbit 10 mg/24 hours mild; Eye-rabbit 0.75 mg severe |
| flammability hazard characteristics | combustible; combustion produces stimulating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidant and alkali. |
| fire extinguishing agent | dry powder, foam, mist water, carbon dioxide |
| auto-ignition temperature | 545 °F |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:06
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