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Palmitoylethanolamide

Palmitoylethanolamide(PEA)

CAS: 544-31-0

Molecular Formula: C18H37NO2

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Palmitoylethanolamide - Names and Identifiers

Name Palmitoylethanolamide(PEA)
Synonyms Palmidrol
PEA PALMIDROL
PALMITYLETHANOLAMIDE
PALMITOYLETHANOLAMIDE
N-HEXADECANOYLETHANOLAMINE
Palmitoylethanolamide(PEA)
N-(2-HYDROXYETHYL)HEXADECANAMIDE
n-(2-hydroxyethyl)-hexadecanamid
PALMITOYLETHANOLAMIDE N-(2-HYDROXYETHYL)HEXADECANAMIDE
CAS 544-31-0
EINECS 208-867-9
InChIKey HXYVTAGFYLMHSO-UHFFFAOYSA-N

Palmitoylethanolamide - Physico-chemical Properties

Molecular FormulaC18H37NO2
Molar Mass299.49
Density0.910±0.06 g/cm3(Predicted)
Melting Point97-98℃
Boling Point461.5±28.0 °C(Predicted)
Water Solubility4.01mg/L at 20℃
Solubility Soluble in DMSO (20 mM), ethanol (25 mM), chloroform, THF ( at 30 °C), and DMF (~10
Vapor Presure0.45Pa at 20℃
AppearanceWhite solid
ColorWhite
pKa14.49±0.10(Predicted)
Storage Condition-20°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
SensitiveSensitive to heat
In vitro studyPEA can effectively prevent rat cerebellar granule cells from glutamate toxicity and enhance the motility of microglia. In the mitochondrial fragments of cells stimulated by PEA, the expression of steroid synthesis rapid regulator protein (StAR) and P450scc, which include some neurosteroid formation proteins, is increased. PEA also has protective effects, such as reducing malondialdehyde formation in cells treated with (S,R)-sulfoximine, the L-buthionine that causes glutathione deficiency. The effect of PEA can be partially inhibited by finasteride (5a-reductase inhibitor).
In vivo studyPEA attenuated the inflammatory response in wild-type mice, but had no effect in ppar-α-deficient mice. PEA can inhibit peripheral inflammation, mast cell degranulation and exert neuroprotective and analgesic effects in mice and rats. At the same time, NO production, neutrophil influx, and expression of pro-inflammatory proteins such as inducible nitric oxide synthase and cyclooxygenase-2 are altered. In addition, PEA can regulate many physiological processes, including pain perception, seizures and neurotoxicity.

Palmitoylethanolamide - Risk and Safety

WGK Germany2
RTECSML8950000
TSCAYes

Palmitoylethanolamide - Reference Information

LogP3.989 at 20℃
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Overview cetylcarboxamide ethanol (PEA) is an endogenous fatty acid amide that belongs to the class of nuclear factor agonists. It has been shown to bind to nuclear receptors (NRS) and exert a large variety of biological functions associated with chronic pain and inflammation.
action PEA has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties. PEA has been exploring various pain states in people in different clinical trials, on inflammation and pain syndromes.
Application hexadecyl amide ethanol is an intermediate in organic synthesis and pharmaceutical intermediates, which can be used in laboratory research and development process and chemical pharmaceutical research and development process.
biological activity Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide, it can selectively activate PPAR-α in vitro with an EC50 of 3.1±0.4 μm.
TargetValue
PPARα (In HeLa cells) 3.1 μM(EC50)
Last Update：2024-04-09 20:52:54
Palmitoylethanolamide
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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Suzhou Myland Pharm & Nutrition Inc.
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Tricosanoic Acid Impurity 19 ( Palmitoylethanolamide) Request for quotation
CAS: 544-31-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Palmitoylethanolamide(PEA) Request for quotation
CAS: 544-31-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Palmitoylethanolamide Visit Supplier Webpage Request for quotation
CAS: 544-31-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Suzhou Myland Pharm & Nutrition Inc.
Product Name: Palmitoylethanolamide(PEA) Request for quotation
CAS: 544-31-0
Tel: 051266706057
Email: maggie@mylandpharm.com
Mobile: 18656033903
QQ: 1677088563 Click to send a QQ messageSend QQ message
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Palmitoylethanolamide
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