Name | Clofentezine |
Synonyms | APOLLO Apollo Panatac NC 21314 APOLLO(R) Acaristop CLOFENTEZIN CLOFETEZINE CLOFENTEZINE ACARISTOP(R) Clofentezine Apollo? Apollo SC Bis(2-chlorophenyl)-1,2,4,5-tetrazine 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine 3,6-BIS(2-CHLOROPHENYL)-1,2,4,5-TETRAZINE 1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)- |
CAS | 74115-24-5 |
EINECS | 277-728-2 |
InChI | InChI=1/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H |
Molecular Formula | C14H8Cl2N4 |
Molar Mass | 303.15 |
Density | 1.3727 (rough estimate) |
Melting Point | 182-185°C(lit.) |
Boling Point | 457.37°C (rough estimate) |
Flash Point | 290.4°C |
Water Solubility | 2.522ug/L(temperature not stated) |
Vapor Presure | 8.4E-10mmHg at 25°C |
Appearance | neat |
Merck | 13,2398 |
BRN | 7137128 |
pKa | -1.68±0.31(Predicted) |
Storage Condition | 0-6°C |
Refractive Index | 1.6300 (estimate) |
Physical and Chemical Properties | Melting Point: 182.3 |
Use | Is a high efficiency, low toxicity, broad-spectrum acaricide, used to control Apple and other fruit tree crown mites |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
RTECS | XF6860000 |
Toxicity | LD50 in rats, mice (mg/kg): >3200 orally; LC50 (96 hr) in rainbow trout: 100 mg/l (Bryan) |
Raw Materials | Acetic acid Hydrogen peroxide 2-Chlorobenzaldehyde Chlorine hydrazine hydrate Tetrahydrofuran Sodium nitrite Ethyl Alcohol |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
toxicity | Acute oral LD50> mg/kg in male and female rats, acute percutaneous LD50 in rats was 5000mg/kg, acute inhalation LC50 in rats was 9mg/L (4H). It has slight irritation to rabbit skin. Rats and dogs fed the test dose of 40mg/kg feed (2 years) and 50mg/kg feed (1 year). No carcinogenic, teratogenic, mutagenic effects. Wild duck acute oral LD50>3000mg/kg, quail> 7500mg/kg. Safe for fish. Rainbow trout LC50 100mg/L (96H), oral LD50>0.02mg/only bees. |
biological activity | clofenteazine is a growth inhibitor, which has a strong lethal effect on mites. |
Use | tetrazine acaricide, an inhibitor of embryonic development, which mainly kills the eggs, but also has a certain effect on the young mites, no effect on adult mites. The effect is slow, the sustained effect period is 50 ~ 60d, and the highest acaricidal effect can be achieved 2~3 weeks after administration. For fruit trees, peas, citrus, ornamental plants, cotton and other crops, the control of whole claw mites and spider mites, the whole claw mites (Apple Red Spider) of the winter eggs is particularly effective. Safe for predatory mites and beneficial insects. In general, 1 times before and after flowering, each time according to the concentration of 100 ~ 125mg/L spray. It is a high-efficiency, low-toxicity and broad-spectrum acaricide, which is used to control mites on the crown of Apple and other fruit trees |
production method | (2-ClC6H4CClN)2 is prepared by the interaction of O-chlorobenzaldehyde with sodium nitrite and chlorine, alternatively, (2-ClC6H4CClN)2 is prepared by reacting 2-chlorobenzoyl chloride with N2H4 (diluted with ethanol) and then with pcl5. Finally, it is reacted with hydrazine hydrate in the presence of a phase transfer catalyst to produce tetra-acarazine. |