Paradiazine
pyrazine
CAS: 290-37-9
Molecular Formula: C4H4N2
Paradiazine - Names and Identifiers
| Name | pyrazine |
| Synonyms | Piazine Pyrazin pyrazine FEMA 4015 p-Diazine Paradiazine 1,4-Diazine 1,4-Diazabenzene FEMA NUMBER 4015 |
| CAS | 290-37-9 |
| EINECS | 206-027-6 |
| InChI | InChI=1/C4H4N2/c1-2-6-4-3-5-1/h1-4H |
Paradiazine - Physico-chemical Properties
| Molecular Formula | C4H4N2 |
| Molar Mass | 80.09 |
| Density | 1.031 g/mL at 25 °C (lit.) |
| Melting Point | 50-56 °C (lit.) |
| Boling Point | 115-116 °C (lit.) |
| Flash Point | 132°F |
| JECFA Number | 951 |
| Water Solubility | SOLUBLE |
| Solubility | Soluble in water, ethanol, ether, etc. |
| Vapor Presure | 19.7mmHg at 25°C |
| Appearance | White crystal |
| Specific Gravity | 1.031 |
| Color | White |
| Merck | 14,7957 |
| BRN | 103905 |
| pKa | 0.65(at 27℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Highly flammable. Incompatible with acids, oxidizing agents. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5235 |
| MDL | MFCD00006122 |
| Use | Used as pharmaceutical intermediates, Essence, Fragrance Intermediates |
Paradiazine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1325 4.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UQ2015000 |
| TSCA | T |
| HS Code | 29339990 |
| Hazard Class | 4.1 |
| Packing Group | III |
Paradiazine - Nature
Open Data Verified Data
colorless crystals. Density 1. 0311. Melting point 54 °c. Boiling point 115~116 deg C. Soluble in water and ether, and water can form a constant boiling mixture. Is a weak monobasic base. Oxidation with hydrogen peroxide in acetic acid yields the N-oxide. Pyrazine itself can not occur nitration and sulfonation reaction, but ring
Nitration can occur when the active group is present on the surface. Halogenated mono-halide and polyhalopyrazine. Easy to react with nucleophile, such as with sodium amino acid reaction of 2 amino pyrazine.
Last Update：2024-01-02 23:10:35
Paradiazine - Introduction
Heterocyclic compounds containing two heteronitrogen atoms at positions 1 and 4. It is an isomer to pyrimidine and pyridazine. Soluble in water, alcohol and ether. It has weak aromaticity, similar to pyridine. It is not easy to undergo electrophilic substitution reactions, but it is easy to undergo substitution reactions with nucleophiles.
Last Update：2022-10-16 17:24:18
Paradiazine - Use
Open Data Verified Data
can be prepared from B- hydroxyethylaminoethylamine, N-hydroxyethylethylenediamine (HOCHz CHz NHCHz CH2 NH2) in the presence of Ni/Al2 03 by dehydrogenation at high temperature.
Last Update：2022-01-01 10:53:51
Paradiazine - Reference Information
| FEMA | 4015 | PYRAZINE |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | can be used in food (FAO/WHO,2001). |
| use | used as a pharmaceutical intermediate, flavor and spice intermediate mainly used for the synthesis of meat, chocolate, peanuts and popcorn and other flavors, at the same time, it can also be used as an intermediate for the synthesis of anti-tuberculosis drug pyrazinamide, the diuretic drug ampicrol guanidine and the oral hypoglycemic drug glipizine and other medicines and pesticides. Used to make resins and polymers and pharmaceuticals |
| Production method | It can be prepared by dehydrogenation of β-hydroxyethyleneamine and N-hydroxyethylenediamine (HOCH2CH2NHCH2CH2NH2) at high temperature in the presence of Ni/Al2O3. |
Last Update：2024-04-09 20:49:11
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