Pemoline
Pemoline
CAS: 2152-34-3
Molecular Formula: C9H8N2O2
Pemoline - Names and Identifiers
Pemoline - Physico-chemical Properties
| Molecular Formula | C9H8N2O2 |
| Molar Mass | 176.17 |
| Density | 1.2662 (rough estimate) |
| Melting Point | 255-256°C |
| Boling Point | 307.77°C (rough estimate) |
| Solubility | DMSO: soluble28mg/mL |
| Appearance | solid |
| Color | white |
| pKa | pKa 10.5 (Uncertain) |
| Storage Condition | Store at RT |
| Refractive Index | 1.5570 (estimate) |
| Physical and Chemical Properties | White crystalline powder. Melting Point 256-257 °c (decomposition). Difficult to dissolve in water, ether, acetone and dilute hydrochloric acid. Odorless and tasteless. |
| Use | Central stimulant for ADHD in children |
Pemoline - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | PB8750000 |
| Toxicity | LD50 orally in rats: 500 mg/kg (Schafer) |
Pemoline - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | this product is a central nervous system excitant, which is 20 times as much as caffeine in the excitatory effect. it is used to treat brain dysfunction, mild depression and narcolepsy, etc. But there are many adverse reactions, and they are gradually replaced by tricyclic and tetracyclic antidepressants. The oral LD50 of rats is 500mg/kg. |
| Production method | The benzaldehyde is condensed and hydrolyzed with chloroform to obtain α-hydroxyphenylacetic acid, and then esterified and cyclized to obtain pemoline. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
