Phenacetin

Phenacetin - Names and Identifiers

Name	Phenacetin
Synonyms	pyraphen phenacet coricidin phenazetin phenacitin Phenacetin Phorazetim acetophenetin Para-phenacetin ACETOPHENETIDIN ACETOPHENETIDINE acetylphenetidin p-acetophenetide acet-p-phenalide p-acetphenetidin Acetophenetidine empirin compound paracetophentidin acet-p-phenetidin p-acetophenetidine ACET-P-PHENETIDINE 4-ACETOPHENETIDIDE 4-acetophenetidine p-Ethoxyacetanilide 4'-ethoxyacetanilide ACETYL-P-PHENETIDINE 4'-ETHOXYACETANILIDE aceto-para-phenalide para-Acetophenetidide 1-ACETYL-P-PHENETIDIN aceto-para-phenetidide N-acetyl-p-phenetidine N-Acetyl-4-ethoxyaniline 1-acetamido-4-ethoxybenzene N-(4-ethoxyphenyl)-acetamide
CAS	62-44-2
EINECS	200-533-0
InChI	InChI=1/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
InChIKey	CPJSUEIXXCENMM-UHFFFAOYSA-N

Phenacetin - Physico-chemical Properties

Molecular Formula	C10H13NO2
Molar Mass	179.22
Density	1.1248 (rough estimate)
Melting Point	133-136 °C (lit.)
Boling Point	132 °C / 4mmHg
Flash Point	2℃
Water Solubility	0.076 g/100 mL
Solubility	Insoluble in water, slightly soluble in ether, slightly soluble in boiling water, soluble in ethanol and chloroform. When dissolved in concentrated sulfuric acid, it does not show color. After dropping nitric acid into the solution, it will be orange-yellow.
Vapor Presure	3.21E-05mmHg at 25°C
Appearance	White crystalline powder
Color	White
Merck	14,7204
BRN	1869238
pKa	pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)
Storage Condition	Sealed in dry,Room Temperature
Stability	Stable. Incompatible with strong oxidizing agents, strong acids.
Sensitive	Hygroscopic
Refractive Index	1.5710
MDL	MFCD00009094
Physical and Chemical Properties	White lustrous scaly crystals or white crystalline powder. The melting point of 137-138 deg C, the refractive index of 1.571. Insoluble in water, slightly soluble in ether, slightly soluble in boiling water, soluble in ethanol and chloroform. Dissolved in concentrated sulfuric acid does not show color, into the solution after dropping nitric acid is orange yellow. No odor, slightly bitter taste.
Use	Antipyretic analgesic

Phenacetin - Risk and Safety

Risk Codes	R45 - May cause cancer R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R11 - Highly Flammable
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3
RTECS	AM4375000
TSCA	Yes
HS Code	29251995
Toxicity	LD50 orally in rats: 1.65 g/kg (Boyd)

Phenacetin - Upstream Downstream Industry

Raw Materials

p-Phenetidine
Acetic acid
Acetic anhydride

Phenacetin - Reference

Reference

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4. Wei Wenzeng, Zhao Ningning, Lin Yingyan, Wang Jin, Wang Gong. Evaluation of the effect of ethanol extract of Antrodia camphorata on the activity of human CYP450 by Cocktail probe [J]. Science and Technology Wind, 2021(03):139-140.
5. Wei Wenzeng, Zhao Ningning, Lin Yingyan, Wang Jin, Wang Gong. Evaluation of the effect of ethanol extract of Antrodia camphorata on the activity of human CYP450 by Cocktail probe [J]. Science and Technology Wind, 2021(03):139-140.