Phenpiazine
quinoxaline
CAS: 91-19-0
Molecular Formula: C8H6N2
Phenpiazine - Names and Identifiers
| Name | quinoxaline |
| Synonyms | Quinazine Phenpiazine usafek-7094 quinoxaline QUINOXALINE USAF EK-7094 Phenopiazine 1,4-Benzodiazine 1,4-Benxodiazine 1,4-Naphthyridine |
| CAS | 91-19-0 |
| EINECS | 202-047-4 |
Phenpiazine - Physico-chemical Properties
| Molecular Formula | C8H6N2 |
| Molar Mass | 130.15 |
| Density | 1.124 g/mL at 25 °C (lit.) |
| Melting Point | 29-32 °C (lit.) |
| Boling Point | 220-223 °C (lit.) |
| Flash Point | 209°F |
| Water Solubility | SOLUBLE |
| Solubility | Ethanol |
| Vapor Presure | 0.105mmHg at 25°C |
| Appearance | Yellow to Orange to Brown Liquid |
| Color | Light yellow to brown |
| Merck | 14,8078 |
| BRN | 109351 |
| pKa | 0.56(at 20℃) |
| Storage Condition | 2-8°C |
| Stability | Light Sensitive |
| Refractive Index | nD48 1.6231 |
| MDL | MFCD00006719 |
| Physical and Chemical Properties | White crystal. Melting point 28 ℃(29-30 ℃), boiling point 229 ℃,140 ℃(5.33kPa),108-110 ℃(1.6kPa), relative density 1.1334(40/4 ℃), refractive index 1.6231(40 ℃). Easily soluble in water, alcohol, ether, benzene. The monohydrate melting point of the product is 37 ℃. |
Phenpiazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | VD1225000 |
| TSCA | Yes |
| HS Code | 29339990 |
| Hazard Note | Irritant |
Phenpiazine - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | is useful as an intermediate for the antituberculosis drug pyrazinamide. |
| production method | is obtained by cyclization of O-Phenylenediamine and glyoxal. Water was added to the reaction Pan, sodium bisulfite was added, and the mixture was stirred. Glyoxal was slowly added, and the temperature was raised to 75-80 ° C. To precipitate white crystals. Stirring was continued for 10min, then water and O-phenylenediamine were added, and the temperature was maintained at 75-80 ° C. For 1H. It was cooled to 50 ° C., neutralized to pH = 8 with sodium carbonate, heated to 60 ° C., and the aqueous layer was separated after standing, and benzopyrazine with a content of 80% was obtained in a yield of 90%. |
Last Update：2024-04-09 20:49:11
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