Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone
Cearoin
CAS: 52811-37-7
Molecular Formula: C14H12O4
Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone - Names and Identifiers
Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone - Physico-chemical Properties
| Molecular Formula | C14H12O4 |
| Molar Mass | 244.24 |
| Density | 1.296±0.06 g/cm3(Predicted) |
| Melting Point | 188 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 443.8±45.0 °C(Predicted) |
| pKa | 8.25±0.48(Predicted) |
| Storage Condition | 2-8℃ |
Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone - Reference Information
| biological activity | Cearoin can be isolated from Dalbergia dorifera, autophagy is enhanced and apoptosis is induced by promoting ROS production and activating ERK. |
| Cell Line: | Human neuroblastoma SH-SY5Y cells Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 1, 5, 10, 20, 40, or 80 μM 0, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 6 or 12 hours 12 hours |
| Result: | Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner. |
Last Update：2024-04-09 15:16:54
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