Phenylacetophenone)
Ethanone, 1-(1,1'-biphenyl)-4-yl-
CAS: 92-91-1
Molecular Formula: C14H12O
Phenylacetophenone) - Names and Identifiers
| Name | Ethanone, 1-(1,1'-biphenyl)-4-yl- |
| Synonyms | 4-Acetylbiphenyl 4-ACETYLBIPHENYL 4'-ACETYLBIPHENYL Phenylacetophenone) 4-PHENYLACETOPHENONE 4-Phenylacetophenone 4'-PHENYLACETOPHENONE 4-DIPHENYLMETHYLKETONE 4-BIPHENYL METHYL KETONE 4-BIPHENYLYL METHYL KETON 4-Biphenylyl methyl ketone 2-MESITYLENECARBOXYLIC ACID 1-(1,1-biphenyl-4-yl)ethanone Ethanone, 1-(1,1'-biphenyl)-4-yl- 4-Acetylbiphenyl, (4-Biphenylyl methyl ketone |
| CAS | 92-91-1 |
| EINECS | 202-202-6 |
| InChI | InChI=1/C14H12O/c1-11(15)12-7-9-14(10-8-12)13-5-3-2-4-6-13/h2-10H,1H3 |
Phenylacetophenone) - Physico-chemical Properties
| Molecular Formula | C14H12O |
| Molar Mass | 196.24 |
| Density | 1.2510 |
| Melting Point | 152-155°C(lit.) |
| Boling Point | 325-327 °C |
| Flash Point | 168°C/8mm |
| Water Solubility | insoluble |
| Solubility | chloroform: soluble10mg/200microlitres, clear, colorless to faintly yellow |
| Appearance | Light brown solid |
| Color | White to Green to Brown |
| BRN | 1101615 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5920 (estimate) |
| MDL | MFCD00008749 |
| Physical and Chemical Properties | Melting point 118-123°C boiling point 325-327°C water-soluble insoluble |
| Use | Used as a pharmaceutical Intermediate |
Phenylacetophenone) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | DI0887010 |
| TSCA | Yes |
| HS Code | 29143900 |
Phenylacetophenone) - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| preparation | biacetophenone is a biphenyl compound that can be prepared from aryl halides or trifluoroborate salts with aryl boronic acid and palladium catalysts, prepared by suzuki-miyura and Buchwald-Hartwig reaction. (1) biphenyl 1542g(10mol) acetic anhydride 1021g(10mol), 4-dimethylaminopyridine (15.42g) and dichloromethane (20000ml) were mixed until used. (2) mix 2825G (21.2mol) of aluminum trichloride with 27000ml of dichloromethane, cool to -10 ℃ ~-20 ℃, the mixture solution of the above-mentioned biphenyl, acetic anhydride, 4-dimethylaminopyridine and dichloromethane is added dropwise with stirring at -10 °c to -20 °c for 60-90 minutes, keep the reaction temperature for 1~2 hours, slowly drop hydrochloric acid solution at -10 ℃ ~-20 ℃, wash with water three times, dry with anhydrous magnesium sulfate, remove methylene chloride under reduced pressure, an off-white solid (2) of 1.831kg was obtained. The yield was 93.3% and the melting point was 121~123 °c. |
| Application | biacetophenone is an important fine chemical intermediate, which is widely used in the chemical synthesis of pesticides, pharmaceuticals and so on. Biacetophenone (Ⅰ) is one of the important intermediates in the synthesis of biphenylacetic acid, and its purity directly affects the purity of biphenylacetic acid. |
| Use | an intermediate of the anti-inflammatory agent biphenylacetic acid. used as pharmaceutical intermediates |
| production method | prepared by acetylation of biphenyl with acetyl chloride or acetic anhydride. |
Last Update：2024-04-09 20:45:29
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