Piperidine, polymer-bound
Piperidine
CAS: 110-89-4
Molecular Formula: C5H11N
Piperidine, polymer-bound - Names and Identifiers
| Name | Piperidine |
| Synonyms | PIP PPR Piperidine PIPERIDINE perhydroazine Hexahydropyridine Pentamethylenimin Pentamethylenimine PENTAMETHYLENEIMINE piperidine phosphate 1-Oxa-4-azacyclohexane Piperidine, polymer-bound PIPERIDINE ON RASTA RESIN Piperidine (Controlled Chemical) |
| CAS | 110-89-4 |
| EINECS | 203-813-0 |
| InChI | InChI=1/H8N6/c1-3-5-6-4-2/h3-6H,1-2H2 |
Piperidine, polymer-bound - Physico-chemical Properties
| Molecular Formula | C5H11N |
| Molar Mass | 85.15 |
| Density | 0.930g/mLat 20°C |
| Melting Point | -11 °C |
| Boling Point | 106°C(lit.) |
| Flash Point | 16°C(lit.) |
| JECFA Number | 1607 |
| Water Solubility | Miscible |
| Solubility | miscible in water and alcohol; soluble in ether, acetone, benzene andchloroformmaximum allowable concentration: not established; more toxic, irritating andvolatile than pyridine (Reinhardt and Brittelli 1981). |
| Vapor Presure | 23 mm Hg ( 20 °C) |
| Vapor Density | 3 (vs air) |
| Merck | 14,7468 |
| BRN | 102438 |
| pKa | 11.123(at 25℃) |
| PH | 12.6 (100g/l, H2O, 20°C) |
| Storage Condition | Store in dark! |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids, organic acids, water. Vapours may flow along surfaces to a distant source of ignition. |
| Sensitive | Air Sensitive |
| Explosive Limit | 1.5-10.3%(V) |
| Refractive Index | n20/D 1.452(lit.) |
| Physical and Chemical Properties | Colorless to light yellow liquid. Ammonia, Fish seems offensive smell. Boiling point 106 °c. |
| Use | Used as a synthetic drug intermediates, rubber accelerator raw materials and epoxy resin curing agent |
Piperidine, polymer-bound - Risk and Safety
| Risk Codes | R61 - May cause harm to the unborn child R10 - Flammable R20/21 - Harmful by inhalation and in contact with skin. R34 - Causes burns R23/24 - R11 - Highly Flammable R52 - Harmful to aquatic organisms R24 - Toxic in contact with skin R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3286 3/PG 2 |
| WGK Germany | 3 |
| RTECS | TM3500000 |
| FLUKA BRAND F CODES | 3-34 |
| TSCA | Yes |
| HS Code | 29333210 |
| Hazard Class | 8 |
| Packing Group | I |
| Toxicity | LD50 orally in rats: 0.52 ml/kg (Smyth) |
Piperidine, polymer-bound - Upstream Downstream Industry
| Downstream Products | cloperastine benproperine phosphate |
Piperidine, polymer-bound - Nature
Open Data Verified Data
colorless clear liquid with ammonia-like odor. Relative density (water 1)0.86. Melting Point -7 °c. Boiling point 106 °c. The vapor pressure is 5.33kPa/29.2 °c. Flash point 16 °c. Refractive index 1.4534. Can be mixed with water. Soluble in alcohol, benzene, chloroform, etc. Strongly alkaline. Toxic nitrogen oxide gas is produced by decomposition at high heat. Can react strongly with oxidizing agents. In case of open flame combustion, and release of toxic gases.
Last Update：2024-01-02 23:10:35
Piperidine, polymer-bound - Safety
Open Data Verified Data
- Moderate acute toxicity: LD50 50mg/kg (Rat oral),320mg/kg (Rabbit transdermal),LC50 6000mg/m3. 2 hours (Mouse Inhalation) irritation: rabbit eye, 20mg (24 hours), severe stimulation; Rabbit skin, 500mg (24 hours), moderate stimulation. Invasive route: inhalation, ingestion, percutaneous absorption. It is a strong irritant to the eyes and skin and is a pressure booster. Small doses can stimulate the sympathetic and parasympathetic ganglia, large doses but have inhibitory effect, can cause weakness, Nausea, salivation, Dyspnea, muscle paralysis and asphyxia. Flammable, in case of fire, combustion will release toxic gases. Toxic nitrogen oxide smoke is released by thermal decomposition. A strong reaction with an oxidizing agent can occur. Combustion (decomposition) products: carbon monoxide, carbon dioxide, nitrogen oxides.
- Protection Measure respiratory system protection: wear self-priming filter type gas mask (full face mask) when possible contact with its vapor. In case of emergency rescue or evacuation, it is recommended to wear an oxygen respirator. Eye protection: protection has been made in respiratory protection. Physical Protection: wear adhesive clothing. Hand Protection: wear anti-benzene oil-resistant gloves. Other: no smoking at work site. After work, take a shower and change clothes. Pay attention to personal hygiene.
- first aid measures skin contact: remove contaminated clothing and rinse the skin thoroughly with soap and water. The patient visited hospital. Eye contact: lift the eyelids immediately and rinse thoroughly with plenty of running water or saline for at least 15 min. The patient visited hospital. Inhalation: rapid departure from the scene to fresh air. Keep airway unobstructed. Such as Dyspnea, to the delivery of oxygen. If breathing stops, perform artificial respiration immediately. The patient visited hospital. Ingestion: drink enough warm water to induce vomiting.
Last Update：2022-01-01 10:53:05
Piperidine, polymer-bound - Use
Open Data Verified Data
used as solvent, organic synthesis intermediate, epoxy resin crosslinking agent, condensation catalyst. Is a strong organic base. Mainly in the pharmaceutical industry for the preparation of piperidine nitrate, piperidine hydrochloride and other drugs. It is also used in organic synthesis in the rubber industry and in the plastics industry. It is also used as a curing agent for epoxy resins. As a chemical reagent, it is mainly used for the identification of cobalt, gold, etc.
Last Update：2022-01-01 10:53:05
Piperidine, polymer-bound - Reference Information
| FEMA | 2908 | PIPERIDINE |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| content analysis | determined by gas chromatography (GT-10-4) with polar column. |
| toxicity | GRAS(FEMA;FDA,§ 1 72.515,2000). |
| usage limit | FEMA(mg/kg): beverage 3.0; Candy 5.0; Baked food 0.05~5.0; Seasoning 0.05; Soup (material) 0.05. Moderate limit (FDA,§ 172.515,2000). |
| use | edible spices. Used as a condensing agent and solvent in organic synthesis Used as an analytical reagent Hexahydropyridine, also known as piperidine, is an intermediate of the plant growth regulator mepiperium. Piperidine, also known as hexahydropyridine, is an intermediate of the fungicide benzidine and the plant growth regulator meperium. piperidine is used to manufacture local anesthetics, analgesics, fungicides, wetting agents, epoxy resin curing agents, rubber vulcanization accelerators, etc. Used as an intermediate for synthetic drugs, raw materials for rubber accelerators and epoxy resin curing agents, etc. |
| Production method | is obtained by catalytic hydrogenation of pyridine. Add pyridine and nickel catalyst into an autoclave, add hydrogen when heated to 50 ℃, and continue to heat and pass hydrogen until 200 ℃, and the hydrogen pressure is nearly 7MPa and no hydrogen is absorbed. The reaction liquid is filtered, the filtrate is fractionated, and the distillate at 102-108 ℃ is collected to obtain piperidine. Another preparation method is to heat pyridine in anhydrous ethanol, add metal sodium, after the reaction, distill with steam, evaporate piperidine and ethanol, neutralize with hydrochloric acid and evaporate the ethanol to obtain piperidine hydrochloride, Treated with sodium hydroxide to obtain free piperidine. The preparation method is obtained by catalytic hydrogenation of pyridine as raw material. The catalyst is Laney nickel, the temperature gradually rises from 50 ℃ to 200 ℃, and the pressure is up to 5~7 MPa. Hydrogen is passed until it is not absorbed, the reaction liquid is filtered, and the fraction at 102~108 ℃ is collected by filtrate distillation. the preparation method is to mix pyridine and lanini nickel catalyst evenly and place them in an autoclave, replace the air in the autoclave with hydrogen, heat to 50 ℃, pass hydrogen 5000 kPa, continue to heat to 150 ℃, stir, gradually reduce the pressure to 1000kPa, continue to rise to 150~200 ℃, add hydrogen to 7000kPa, after reaction, the pressure is reduced to 1000kPa, and then pass hydrogen to 7000kPa at 200 ℃, hydrogen is passed about 6~7 times until hydrogen is no longer absorbed. When the reaction solution is reduced to about 70 ℃, the supernatant is taken for filtration, and the filtrate is fractionated to obtain the product. Made by electrolytic reduction of pyridine. |
| category | flammable liquid |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 400 mg/kg; Oral-mouse LD50: 30 mg/kg |
| stimulation data | skin-rabbit 5 mg/24 hours severe; Eye-rabbit 250 micrograms/24 hours severe |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; Thermal decomposition of toxic nitrogen oxide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam |
| spontaneous combustion temperature | 320°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:48:19
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