Pironetin
Pironetin
CAS: 151519-02-7
Molecular Formula: C19H32O4
Pironetin - Names and Identifiers
Pironetin - Physico-chemical Properties
| Molecular Formula | C19H32O4 |
| Molar Mass | 324.45 |
| Density | 0.993±0.06 g/cm3(Predicted) |
| Melting Point | 75-77 °C |
| Boling Point | 473.1±40.0 °C(Predicted) |
| pKa | 14.28±0.20(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
Pironetin - Reference Information
| biological activity | Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization with cell cycle arrest and antitumor activity. |
| Target | microtumule |
| Cell Line: | 3Y1 cells HeLa, A2780 and K-NRK cells |
| Concentration: | 20 ng/mL, 50 ng/mL, 100 ng/mL 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL |
| Incubation Time: | 24 hours 3 days |
| Result: | Arrested the cell cycle progression at G2/M in3Y1 cells. Inhibited the cell proliferation. Showed a moderate antitumor effect. |
| Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells |
| Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
Last Update：2024-04-09 20:49:11
