Polyether polyol
synperonic pe(R)|F68
CAS: 9003-11-6
Molecular Formula: CxHyOz
Polyether polyol - Names and Identifiers
| Name | synperonic pe(R)|F68 |
| Synonyms | Polyether polyol Polyoxyethylene-polyoxypropylene Block Copolymer Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) |
| CAS | 9003-11-6 |
| EINECS | 618-355-0 |
| InChI | InChI=1/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
Polyether polyol - Physico-chemical Properties
| Molecular Formula | CxHyOz |
| Molar Mass | 102.13 |
| Density | 1.095 g/mL at 25 °C |
| Melting Point | 60-50℃ |
| Boling Point | >200 °C(lit.) |
| Flash Point | >230 °F |
| Water Solubility | Miscible with water. |
| Vapor Presure | <0.3 mm Hg ( 20 °C) |
| Vapor Density | >1 (vs air) |
| Appearance | Morphological solution, color APHA: ≤ 120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.466 |
| MDL | MFCD00082049 |
| Physical and Chemical Properties | Chemical properties colorless to yellow transparent liquid. Soluble in water. |
| Use | Use Defoamer. The defoaming effect is 25~30 times higher than that of soybean oil. An aqueous solution with a concentration of 3% to 5% is usually used. |
Polyether polyol - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R21 - Harmful in contact with skin R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | TP6164333 |
| TSCA | Yes |
| HS Code | 39059100 |
| Toxicity | LD50 oral in rabbit: 35gm/kg |
Polyether polyol - Upstream Downstream Industry
Polyether polyol - Standard
Authoritative Data Verified Data
This product is an a-hydrogen-or hydroxy Poly (oxyethylene) a-Poly (oxypropylene) Poly (oxyethylene) a block copolymer. The block copolymer is formed by the reaction of propylene oxide and propylene glycol to form a polyoxypropylene glycol followed by the addition of ethylene oxide. In the copolymer, the content of oxyalkylene units U) is 75 to 85, the content of oxypropylene units (6) is 25 to 30, and the content of oxyethylene EO) is 79. 9% ~ 83. The average molecular weight was 7680 to 9510.
Last Update：2024-01-02 23:10:35
Polyether polyol - Trait
Authoritative Data Verified Data
- This product is a white translucent waxy solid with slight abnormal odor.
- This product is soluble in water and ethanol, soluble in anhydrous ethanol or ethyl acetate, and almost insoluble in ether or petroleum ether.
Last Update：2022-01-01 11:23:43
Polyether polyol - Introduction
Synperonic PE (R) or F68) is a polymer with various industrial applications. Here is a brief introduction to its properties, uses, manufacturing methods, and safety information:
nature:
1. Chemical structure: Poloxamer is a copolymer of polyvinyl alcohol (PEG) and polypropylene glycol (PPG), with a molecular weight typically ranging from thousands to tens of thousands.
2. Appearance: It is usually a colorless or pale yellow liquid or powder with good fluidity.
3. Solubility: It can dissolve well in water and also has some solubility in polar solvents and certain oils.
4. Surfactant properties: It has good emulsifying, wetting, and dispersing properties.
5. Temperature sensitivity: Under certain conditions, especially at different temperatures and concentrations, it can exhibit different physical and chemical properties.
Purpose:
Biotechnology: As a non-ionic surfactant in the fields of cell culture, gene transfer, and other biotechnology.
Manufacturing method:
Poloxamer is usually prepared by polymerization reaction. The specific methods include:
1. Aggregation reaction: The copolymerization of epoxy compounds (such as ethylene oxide and propylene oxide) in the presence of a catalyst is carried out to prepare polymers of the desired molecular weight.
2. Post processing: After separation, drying, and crushing processes, the final product is obtained.
3. Quality control: The product undergoes strict quality testing to ensure that its performance meets application standards.
Security information:
1. Toxicity: It is generally believed that poloxamer is low toxicity, but the specific toxicity characteristics may depend on the specific form and concentration of the product. It is usually recommended to avoid direct contact with the skin and eyes.
2. Handling and storage: It should be stored in a well ventilated place, avoiding high temperatures and direct sunlight.
3. Emergency measures: If in contact with eyes or skin, rinse immediately with plenty of water. If discomfort occurs, seek medical assistance.
4. Environmental impact: Pay attention to the potential impact on the environment when using it, and dispose of it in accordance with local regulations.
Last Update：2024-09-05 08:25:46
Polyether polyol - Differential diagnosis
Authoritative Data Verified Data
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1 8 figure).
Last Update：2022-01-01 11:23:43
Polyether polyol - Exam
Authoritative Data Verified Data
pH
take this product l .O g, add water 10ml to dissolve, according to the determination (General 0631) ,p H value should be 5.0~7. 5.
clarity and color of solution
take the solution under the item of pH, check according to the law of general principles 0901 and 0902), should be clear and colorless.
poly (ethylene oxide)
take this product 0. 1 to 0 .2G, dissolved with deuterated water lm l containing 1% sodium 4, 4-dimethyl-4-pentane sulfonate or deuterated trimethane lm l containing 1% tetramethylsilane; put the sample solution into the nuclear magnetic resonance tube, if the chloroform is used as the solvent, add 1 drop of deuterated water, shake, in the nuclear magnetic resonance instrument, from 0 to 5x 1 (TS scan, quantitative analysis by direct comparison method.
degree of unsaturation
weigh the product after grinding about 15. 0g, add 50ml Mercury acetate solution accurately, under magnetic stirring to dissolve completely, stand for 30 minutes, shake intermittently, add sodium bromide crystallization lOg, mix for 2 minutes under magnetic stirring, immediately fl phenolphthalein indicator solution 1ml, with methanol potassium hydroxide titration solution (0. lnaol/L) titration, corrected for blank test and initial acidity [take Poloxamer 15. Og, add neutral methanol (phenolphthalein refers to the east liquid neutral) 75ml dissolved, with methanol potassium hydroxide titration solution (0. lm o l/L) neutralized to neutral to phenolphthalein indicator solution].
average molecular weight
take the right amount of this product (about equivalent to the molecular weight of X0.002g), Precision weighing, Precision Add phthalic anhydride-pyridine solution 25ml, plus a small amount of zeolite, heating reflux for 1 hour, cool, rinse the condenser with pyridine twice, 10ml each time, add 10ml of water, mix well, plug and place for 10 minutes, add 0. 6 6mol/L sodium hydroxide solution 50ml, then phenolphthalein-pyridine solution (1 -100)0.5 m l, with sodium hydroxide titration solution (0.5 M o l/L) titration, micro pink, for 15 seconds does not fade, and the results of the titration with a blank test correction, that is.
epoxy ethylene, epoxy propylene, 1,4 dioxane
take this product lg, precision weighing, top empty bottle, precision plus dimethylformamide 5ml, shake, seal, as a test solution. In addition, an appropriate amount of ethylene oxide, propylene oxide and 1, 4-dioxane is taken and diluted with dimethylformamide to make 0.2 UG, lU g and solution per lm l, and 5 m l of the above solution is accurately measured, in a top empty bottle, sealed, as a control solution. As determined by gas chromatography (General 0521), with 6% cyanopropyl phenyl-94% dimethyl polysiloxane as stationary liquid capillary column (0. 25mm x 30m), column temperature: starting temperature 7 0°C, rising to 220QC at a rate of 35°C per minute for 5 minutes; Hydrogen flame ionization detector, detector temperature 2 8 0°C; the inlet temperature was 250°C. The equilibrium temperature of the headspace bottle was 80°C and the incubation time was 30 minutes. The control solution is injected in the headspace, and the separation degree between the ethylene oxide peak, the propylene oxide peak and the 1, 4-dioxane peak shall meet the requirements. Then take the test solution and the control solution into the headspace respectively, record the chromatogram, and calculate the peak area according to the external standard method. The content of ethylene oxide should not exceed 0.0001%, propylene oxide should not pass 0. 0005%,1, 4-dioxane was not allowed to pass 0, 0005%.
ethylene glycol and diethylene glycol
take an appropriate amount of 1, 3-butanediol, weigh it precisely, add anhydrous ethanol and dilute it to make lm l containing O.Olmg solution as internal standard solution; Take this product O. lg, precision weighing, in 25ml measuring flask, precision plus internal standard solution lm l, diluted with anhydrous ethanol to the scale, shake, filter, take the filtrate as the test solution; take the appropriate amount of ethylene glycol and diethylene glycol, precision weighing, dissolved and diluted with anhydrous ethanol to make each lm l containing 0. Olmg mixed solution, measuring the mixed solution lm l, put in 25ml measuring flask, precision plus internal standard solution lm l, diluted with anhydrous ethanol to the scale, shake, as a control solution. According to gas chromatography (General 0521), phenyl-polydimethylsiloxane (50: 50) was used as the stationary phase. The initial temperature is 608C, maintained for 5 minutes, increased to 100°C at a rate of 10°C per minute, then increased to 170°C at a rate of 4°C per minute, and finally increased to 270°C at a rate of 10°C per minute, it was maintained for 2 minutes. The inlet temperature was 270°C and the detector temperature was 290°C. The test solution and the control solution are injected into the gas chromatograph, and the peak area is calculated according to the internal standard method. The content of ethylene glycol and diethylene glycol shall not exceed 0. 01%.
propylene glycol
take an appropriate amount of this product, precision weighing, diluted with absolute ethanol to make a solution containing lm g per lm l, as a test solution; Take an appropriate amount of propylene glycol, precision weighing, diluted with absolute ethanol to make about 0. A solution of OOSpg, as a control solution. Determination by gas chromatography (General Rule 0 5 2 1). Polyethylene glycol 2 0m as the stationary phase; The initial temperature is 1 3 (TC, maintain 1 min, at the rate of 10°C per minute to 240°C, maintain 1 min, injection temperature 230X:, detector temperature 250X:. The test solution and the control solution were injected with human gas chromatography in each F1. Calculated by peak area according to external standard method, the content of propylene glycol shall not exceed 0. 0005%.
moisture
take this product, according to the determination of moisture (General 0832 first method), the water content shall not exceed 1.0%.
ignition residue
The l .O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
take l .O g of this product, add 23ml of water to dissolve, add acetate buffer (pH3.5)2ml, check according to law (General rule 0821 second law), containing heavy metals not more than 20 parts per million.
arsenic salt
take this product l.O g, add hydrochloric acid 5M l and water 23ml, shake to dissolve, check according to law (General Rule 0 8 2 2 first law), should comply with the regulations (0 .0 0 0 2).
bacterial endotoxin (for injection)
take this product, check according to law (General rule 1 1 4 3 ), the amount of endotoxin per lm g should be less than 0.012EU.
sterile (for sterile preparations without sterilization process)
take this product, according to the law inspection (General 1101), should comply with the provisions.
Last Update：2022-01-01 11:23:44
Polyether polyol - Category
Authoritative Data Verified Data
pharmaceutical excipients, solubilizers and emulsifiers.
Last Update：2022-01-01 11:23:45
Polyether polyol - Storage
Authoritative Data Verified Data
light shielding, closed storage.
Last Update：2022-01-01 11:23:45
Polyether polyol - Attached
Authoritative Data Verified Data
preparation of Mercury acetate solution
take 50g of Mercury acetate and add glacial acetic acid 0 .5M l of methanol 900ml dissolved, diluted with methanol to 1000ml, shake, such as yellow can not be used; If it is turbid, should be filtered, such as filtration is still turbid or yellow can not be used. This product should be used when the new system. Stored in brown bottles, in the dark.
Preparation and calibration of phthalic anhydride-pyridine solution
- pyridine 500TNL (pyridine water content should be less than 0. 1%; Or take 500ml of pyridine, add 30g of phthalic anhydride, dissolve, distill, take the middle fraction and apply), add 72g of phthalic anhydride, it was shaken vigorously until completely dissolved or heated in a 40°C water bath to completely dissolve, protected from light and left overnight.
- take 1 0 m l of the above solution, add 2 5 m l of pyridine and 5 0 m l of water, mix well, place for 15 minutes, add phenolphthalein-pyridine solution (1- 100)0. 5ml, with sodium hydroxide titration solution (0. 5 m o l/L) titration, the amount of consumed titration solution should be 3 7. 6-4 0. 0ml.
Last Update：2022-01-01 11:23:45
Polyether polyol - Uses and synthesis methods
Open Data Unverified Data
introduction
poloxamer (oloame) is a block copolymer of polyoxyethylene polyoxypropylene ether, the trade name is sillionic (luromio). This is a new type of polymer non-ionic surfactant.
properties
polyoxyethylene is 81.8+1 9%. Poloxamer is easily soluble in water or ethanol, dissolved in absolute ethanol, ethyl acetate, and chloroform, and almost insoluble in ether or petroleum ether. It has a certain foaming property. The pH value of the 2.5% aqueous solution is between 5.0 and 7.5, and the pH value of the injector is between 6.0 and 7.0. The aqueous solution is more stable in the air, and the pH value drops when exposed to light. This product is stable to acid-base aqueous solution and metal ions.
use
poloxamer (poloxamer) is a non-patent name for polyoxyethylene-polyoxypropylene copolymer. The product trade name of the German BASF company is Plannick (Pluronic), in which the polyoxyethylene chain is relatively hydrophilic and the polyoxypropylene chain is relatively lipophilic, so it is a non-ionic polymer surfactant. It is mainly used as emulsifier and solubilizer in pharmaceutical preparations.
Toxicity
can be safely used in food (FDA,& sect;172.828,2000).
use limited
for fermentation process, limited to GMP (GB 2760-96).
Same as "10212, 331 polosammer".
use
1. Used in the manufacture of polyurethane foams, adhesives and elastomers, etc.
2, non-ionic surfactant
3. Stabilizer, solubilizer.
4, for spice concentrate.
5, stabilizer; solubilizer; defoamer; wetting agent for perfume concentrate.
6. as an emulsifier, it can be used in fermentation process according to the regulations of our country and can be used in an appropriate amount according to the production requirements.
7. Biochemical studies
8. Non-ionic surfactants, soft and hard surface cleaners, coatings and defoamers in water treatment. Metal working lubricants, defoaming aids and extents for linear and crosslinked polyesters and polyurethanes.
production method
1. potassium hydroxide reacts with glycerol in a polymerization kettle to generate potassium glycerol; Then at 90~95 ℃ under a pressure of 0.4 ~ 0.5MPa, propylene oxide is continuously added for reaction. After the above reaction, a certain amount of ethylene oxide is added, and polymerization is continued at the same temperature and <0.3MPa pressure. After the reaction is completed, neutralize with oxalic acid to neutral, decolorize with activated carbon, and filter to obtain.
2, obtained by block copolymerization of ethylene oxide and propylene oxide.
3. It is obtained by copolymerization of ethylene oxide and propylene oxide.
4. it is formed by polymerizing glycerol and propylene oxide under potassium hydroxide catalysis and pressure of 90~95 ℃ and 0.4~0.5 MPa, then adding ethylene oxide to polymerize at 90~95 ℃ and <0.3 MPa.
Last Update：2024-04-09 19:43:38
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View History
Polyether polyol
AKOS MSC-0104
(R)-2-氨基-3-甲基丁-1-醇
LABOTEST-BB LT00454955
PHENYL CHLOROFORMATE (PCF)
(3R)-(+)-3-二甲氨基吡咯烷
2-(5-氨基-3-甲基-1H-吡唑-1-基)乙醇
5-溴-2-氯-3-羟基-4-甲基吡啶
2-甲氨基-3-吡啶羧酸
3-氨基-5-溴-4-甲氧基吡啶
AKOS MSC-0104
(R)-2-氨基-3-甲基丁-1-醇
LABOTEST-BB LT00454955
PHENYL CHLOROFORMATE (PCF)
(3R)-(+)-3-二甲氨基吡咯烷
2-(5-氨基-3-甲基-1H-吡唑-1-基)乙醇
5-溴-2-氯-3-羟基-4-甲基吡啶
2-甲氨基-3-吡啶羧酸
3-氨基-5-溴-4-甲氧基吡啶
Raw Materials for Polyether polyol
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