Procaine

Procaine - Names and Identifiers

Name	procaine
Synonyms	procaine novocaine 2-diethylaminoethylp-aminobenzoate 2-diethylaminoethyl4-aminobenzoate 2-diethylaminoethyl 4-aminobenzoate 2-(diethylamino)ethylp-aminobenzoate 2-(Diethylamino)ethyl 4-aminobenzoate 2-(Diethylamino)ethyl p-aminobenzoate 4-Aminobenzoic acid diethylaminoethyl ester 2-diethylaminoethylesterkyselinyp-aminobenzoove 2-Diethylaminoethylester kyseliny p-aminobenzoove
CAS	59-46-1
EINECS	200-426-9
InChI	InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3

Procaine - Physico-chemical Properties

Molecular Formula	C13H20N2O2
Molar Mass	236.31
Density	1.0604 (rough estimate)
Melting Point	61°
Boling Point	378.78°C (rough estimate)
Flash Point	179.8°C
Water Solubility	9.45g/L(30 ºC)
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	8.84E-06mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Merck	14,7757
pKa	pKa 9.04±0.01(H2O,t=25,I=0.1(NaCl))(Approximate)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Stability	Hygroscopic
Refractive Index	1.5430 (estimate)
Physical and Chemical Properties	White crystals. Melting Point 61 °c. The dihydrate has a melting point of 51 ° C., and its hydrochloride ([51-05-8]) is a white crystal or crystalline powder with a melting point of 153-156 ° C. Soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. No odor, slightly bitter taste, followed by a sensation of numbness and itch. Its aqueous solution is easy to decompose and fail after long storage, exposure or heating.
In vitro study	After Procaine treatment, the cell viability of HLE, HuH7 and HuH6 cells decreased significantly. In procaine-treated HLE cells, morphological changes such as vacuolization were found, but the rate of apoptosis was not increased. After procaine treatment, all genes whose transcription was inhibited by DNA methylation were demethylated and reactivated. In human hepatoma cells, procaine has growth inhibitory and demethylating effects.
In vivo study	Procaine has growth inhibitory and demethylating effects on xenografts in vivo.