Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI)
Sevoflurane
CAS: 28523-86-6
Molecular Formula: C4H3F7O
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Names and Identifiers
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Physico-chemical Properties
| Molecular Formula | C4H3F7O |
| Molar Mass | 200.05 |
| Density | 1.505 |
| Boling Point | 58°C |
| Flash Point | 58°C |
| Water Solubility | Slightly miscible with water. |
| Solubility | Slightly soluble in water, miscible with ethanol (96 per cent). |
| Vapor Presure | 311mmHg at 25°C |
| Appearance | neat |
| Specific Gravity | 1.505 |
| Color | Colourless |
| Merck | 14,8475 |
| BRN | 2041023 |
| Storage Condition | Refrigerator |
| Refractive Index | 1.266 |
| Physical and Chemical Properties | Volatile liquid, boiling point 58.1-58.2 ℃/100.1kPa; Boiling point 58.5 ℃/101.3kPa. D4231.55. |
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. S23 - Do not breathe vapour. |
| UN IDs | UN 3334 |
| WGK Germany | 3 |
| RTECS | KO0737000 |
| HS Code | 29091990 |
| Hazard Note | Irritant |
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Standard
Authoritative Data Verified Data
This product is 1,1,1,3,3, 3-hexachloro-2-(chloromethoxy)-propane. The content of C4H3F70 should be 99.9% ~ 100.0%.
Last Update：2024-01-02 23:10:35
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Trait
Authoritative Data Verified Data
- This product is colorless and clear liquid; Volatile, non-flammable.
- This product can be mixed with ethanol or ethyl acetate or chloroform, and is almost insoluble in water.
relative density
the relative density of this product (General 0601 pycnometer method) is 1.521, 1.527.
Last Update：2022-01-01 11:30:40
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Differential diagnosis
Authoritative Data Verified Data
- take this product and SEVOFRANE (Sevoflurane) of the reference substance, respectively, with dichloroethane into solution containing about mg per 1 ml as the test solution and the reference solution, according to the related substances under the chromatographic conditions test, the retention of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
- take this product, measured by gas method, the infrared absorption spectrum should be consistent with the control spectrum (Spectrum set 1108 figure).
Last Update：2022-01-01 11:30:40
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Exam
Authoritative Data Verified Data
pH
take 20ml of this product, add water 20mK after shaking for 3 minutes, Jingdong make stratification, separate the water layer, add 2 drops of bromocresol purple indicator solution, drop add sodium hydroxide liquid (O.Olmol/L) to neutral solution, consumption of sodium hydroxide titration solution (O.Olmol/L) should not exceed the volume of 0.10ml; Or drop manganic acid titration solution (O.Olmol/L) to the solution is neutral, consumption of hydrochloric acid titration solution (0.Olmol/L) in a volume not exceeding 0.30.
halides and free halogens
take 15ml of this product, add 30ml of water, shake for 3 days, take 5ml of water, add 5ml of water, add 1 drop of nitric acid and 0.2 of silver nitrate test solution, in case of turbidity, compared with the control solution prepared by the same method with 10ml of water, it should not be more concentrated. In addition, 10ml of water layer is divided, and lml of cadmium iodide test solution and 2 of starch indicator solution are added, which shall not produce blue color.
Related substances
take a 25ml measuring flask, add this product to the scale, then accurately weigh the rose and add the internal standard substance isopropanol 12mg (about 154 ), shake, as a test solution; another SEVOFRANE (Sevoflurane) reference, hexafluoroisopropanol and isopropanol were accurately weighed and diluted with dichloroethane to make SEVOFRANE (Sevoflurane) 1.5mg, hexafluoroisopropanol 1.5mg, A combined solution of 0.6mg of isopropanol was used as a control solution. According to the method of gas chromatography (General 0521), test the drug, with 6% cyanopropyl phenyl-94% methyl polysiloxane (or polar similar) the capillary column is a chromatographic column (the initial temperature of the membrane thickness is 50°C, which is maintained for 10 minutes, and the temperature is raised to 140°C at a rate of 10°C per minute, which is maintained for 5 minutes; the inlet temperature was 200°C; The detector temperature was 220°C. The reference solution 1 u1 is injected into the gas chromatograph, and the order of peaks is heptafluoroisopropanol, dichloroethane and hexafluoroisopropanol. The number of theoretical plates shall not be less than 5000 based on the peak SEVOFRANE (Sevoflurane), the degree of separation between adjacent peaks shall meet the requirements. The lul of the reference solution and the test solution were respectively injected into the human gas chromatograph, and the chromatogram was recorded. If there are peaks in the chromatogram of the test solution that are consistent with the hexafluoroisopropanol peak retention time, the hexafluoroisopropanol correction factor shall not exceed 0.03% (W/W) according to the internal standard method; other individual impurity peaks shall not exceed 0.05% (W/W) based on the SEVOFRANE (Sevoflurane) correction factor calculated by the internal standard method; The total amount of impurities shall not exceed 0.1%(W/W).
moisture
take this product, according to the determination of moisture (General 0832 first method 1), the water content shall not exceed 0.1%.
Non-volatile
take 50ml of this product, put it on a water bath and slowly evaporate it to dryness, and dry it at 105°C for 2 hours. The remaining residue should not pass lmg.
Last Update：2022-01-01 11:30:41
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Content determination
Authoritative Data Verified Data
take this product, determine the total amount of impurities according to the item of related substances, and subtract the total amount of impurities by 100.0%.
Last Update：2022-01-01 11:30:42
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Category
Authoritative Data Verified Data
inhalation of anesthetics.
Last Update：2022-01-01 11:30:42
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Storage
Authoritative Data Verified Data
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:30:42
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Sevoflurane for Inhalation
Authoritative Data Verified Data
This product is made of SEVOFRANE (Sevoflurane) inhalation agent. SEVOFRANE (Sevoflurane) (C4H3F7O) shall be 99.9% ~ 100.0%.
trait
This product is a colorless clear liquid; Volatile, non-flammable.
identification
The same result was shown in the item SEVOFRANE (Sevoflurane) item test.
examination
- the pH value, Halide, free halogen and related substances shall be checked according to the method under item SEVOFRANE (Sevoflurane) and shall comply with the regulations.
- the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 0.3%, first method 1).
- the device shall be inspected according to the minimum loading capacity inspection method (General rule 0942) and shall comply with the regulations.
Content determination
take this product, according to SEVOFRANE (Sevoflurane) under the method of determination, that is.
category
inhalation of anesthetics.
specification
120ml
storage
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:30:43
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | sevoflurane is a halogenated inhaled general anesthetic, mainly used to induce and maintain anesthesia. Non-flammable, non-explosive, volatile liquid, used after vaporization. Sevoflurane has no corrosive effect on stainless steel, brass, aluminum, nickel-plated brass, chrome-plated brass and copper beryllium. No irritation, it can be miscible with ethanol, ether, chloroform and benzene, slightly soluble in water. |
| pharmacological effects | the minimum alveolar concentration (MAC) of sevoflurane is 1.7% in pure oxygen and 0.66% in the mixed gas of laughing gas and oxygen (2:1), roughly the same as enflurane, about half of halothane. The LC50/MAC ratio is larger than that of enflurane, and the induction time is shorter than that of enflurane and halothane. There is no irritating smell and it wakes up quickly, so it is easy to adjust the depth of anesthesia during anesthesia. In anesthesia, its analgesic effect and muscle relaxation intensity are the same as those of enflurane and halothane; respiratory depression is lighter than halothane; it rarely causes arrhythmia; blood pressure will decrease during the induction of anesthesia, and then gradually stabilize. Sevoflurane is a volatile anesthetic that inhibits the activation of inflammatory neutrophils and granulocytes in human blood during simulated cardiopulmonary bypass. |
| preparation | taking hexafluoroisopropanol and CH2(OCH3)2 as starting materials, adding p-toluenesulfonic acid, stirring at room temperature, adding water and 10% NaOH to adjust pH = 9, dividing the organic layer, washing with water, distilling to obtain methoxymethylene hexafluoroisopropyl ether, adding KF and fuming sulfuric acid, slowly heating to 50 ℃, and collecting steam with an aqueous trap, the organic layer is washed and fractionated to obtain sevoflurane product. The reaction yield is about 80%, and the reaction route is as follows. |
| biological activity | Sevoflurane (Fluoromethyl) is a non-competitive inhibitor of 5-HT3 receptor and can be used as a low-solubility inhalation anesthetic. |
| Target | Value |
| Use | Inhaled anesthetic, its anesthetic effect is roughly the same as enflurane, about half of halothane, and the induction time is shorter than enflurane and halothane, And there is no big difference in awakening time. For general anesthesia. |
| Production method | Using hexafluoroacetone as raw material, it is hydrogenated under the catalysis of palladium-carbon to obtain hexafluoroisopropanol. Hexafluoroisopropanol is reacted with formaldehyde, hydrogen fluoride and sulfuric acid to obtain sevoflurane. It can also react with bromoacetic acid before being treated with bromine trifluoride to obtain sevoflurane. |
| category | toxic substances |
| toxicity classification | low toxicity |
| acute toxicity | oral-rat LD50: 10800 mg/kg; Oral-mouse LD50: 18200 mg/kg |
| flammability hazard characteristics | combustible; combustion decomposition of toxic fluoride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food additives |
| fire extinguishing agent | carbon dioxide, foam, sand, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
